Ads
related to: clozapine n oxidegoodrx.com has been visited by 100K+ users in the past month
"Your pet's prescription needs met at a price you can afford." - Patch
Search results
Results from the WOW.Com Content Network
Clozapine N-oxide (CNO) is a synthetic drug used mainly in biomedical research as a ligand to activate Designer Receptors Exclusively Activated by Designer Drugs (DREADDs), [1] despite the initial belief that it was biologically inert.
Clozapine, sold under the brand name Clozaril among others, is a psychiatric medication and was the first atypical antipsychotic to be discovered. [6] It is primarily used to treat people with schizophrenia and schizoaffective disorder who have had an inadequate response to two other antipsychotics, or who have been unable to tolerate other drugs due to extrapyramidal side effects.
These systems typically utilize G protein-coupled receptors engineered to respond exclusively to synthetic ligands, like clozapine N-oxide (CNO), [4] and not to endogenous ligands. Several types of these receptors exists, derived from muscarinic or κ-opioid receptors. [1]
Clozapine N-oxide, a synthetic ligand which activates a receptor Fulminate , a chemical compound containing the CNO − ion Topics referred to by the same term
Another group generated a family of G-protein coupled receptors that could be activated by the inert small molecule clozapine N-oxide but insensitive to the native ligand, acetylcholine; these receptors are known as DREADDs. [123] Novel functionalities or protein specificity can also be engineered using computational approaches.
Chemical structure of the prototypical NaSSA mirtazapine (original brand name Remeron). Noradrenergic and specific serotonergic antidepressants (NaSSAs) are a class of psychiatric drugs used primarily as antidepressants. [1]
Get AOL Mail for FREE! Manage your email like never before with travel, photo & document views. Personalize your inbox with themes & tabs. You've Got Mail!
Clozapine (Clozaril), an atypical antipsychotic, fell out of favor due to concerns over drug-induced agranulocytosis. Following research indicating its effectiveness in treatment-resistant schizophrenia and the development of an adverse event monitoring system, clozapine re-emerged as a viable antipsychotic.