Search results
Results from the WOW.Com Content Network
Nicotinamide adenine dinucleotide phosphate, abbreviated NADP [1] [2] or, in older notation, TPN (triphosphopyridine nucleotide), is a cofactor used in anabolic reactions, such as the Calvin cycle and lipid and nucleic acid syntheses, which require NADPH as a reducing agent ('hydrogen source'). NADPH is the reduced form, whereas NADP + is the ...
A biological coenzyme that acts as an electron carrier in enzymatic reactions. NADP is a reducing agent in anabolic reactions like the Calvin cycle and lipid and nucleic acid syntheses. NADP exists in two forms: NADP+, the oxidized form, and NADPH, the reduced form.
NADPH oxidase (nicotinamide adenine dinucleotide phosphate oxidase) is a membrane-bound enzyme complex that faces the extracellular space. It can be found in the plasma membrane as well as in the membranes of phagosomes used by neutrophil white blood cells to engulf microorganisms.
Respiratory burst requires a 10 to 20 fold increase in oxygen consumption through NADPH oxidase (NOX2 in humans) activity. NADPH is the key substrate of NOX2, and bears reducing power. Glycogen breakdown is vital to produce NADPH. This occurs via the pentose phosphate pathway.
The NADPH in turn maintains the level of glutathione in these cells that helps protect the red blood cells against oxidative damage from compounds like hydrogen peroxide. [1] Of greater quantitative importance is the production of NADPH for tissues involved in biosynthesis of fatty acids or isoprenoids , such as the liver, mammary glands ...
13058 Ensembl ENSG00000165168 ENSMUSG00000015340 UniProt P04839 Q61093 RefSeq (mRNA) NM_000397 NM_007807 RefSeq (protein) NP_000388 NP_031833 Location (UCSC) Chr X: 37.78 – 37.81 Mb Chr X: 9.3 – 9.35 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse NADPH oxidase 2 (Nox2), also known as cytochrome b(558) subunit beta or Cytochrome b-245 heavy chain, is a protein that in humans is ...
In enzymology, a NADPH dehydrogenase (EC 1.6.99.1) is an enzyme that catalyzes the chemical reaction NADPH + H + + acceptor ⇌ {\displaystyle \rightleftharpoons } NADP + + reduced acceptor The 3 substrates of this enzyme are NADPH , H + , and acceptor , whereas its two products are NADP + and reduced acceptor .
For example, an enzyme that catalyzed this reaction would be an oxidoreductase: A – + B → A + B –. In this example, A is the reductant (electron donor) and B is the oxidant (electron acceptor).