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[312] [313] In one study, 100 mg rectal suppositories of progesterone given five times per day for 9 days resulted in progesterone levels of 5.5 to 29 ng/mL and suppressed circulating testosterone and growth hormone levels by about 50% in men, but did not affect libido or erectile potency in this short treatment period.
[17] [48] Levels of progesterone with 100 mg/day intramuscular progesterone were substantially higher than with 800 mg/day vaginal progesterone (about 70 ng/mL and 12 ng/mL, respectively), although local progesterone levels in the uterus were 10 times higher with the vaginal route due to a uterine first-pass effect (around 1.5 ng/mL and almost ...
Estradiol and norethisterone acetate (Activella, Amabelz) – 1 mg / 0.5 mg; 0.5 mg / 0.1 mg; Ethinylestradiol and norethisterone acetate (FemHRT) – 25 μg / 0.5 mg; Estradiol/progesterone (TX-001HR), a combination of estradiol and progesterone in oil-filled capsules, is currently pending approval. [45]
As of currently, 30 capsules of 100 mg of the generic version, Prometrium, from CVS Pharmacy is around $40 without any discounts or insurance applied. The brand version, Progesterone, is around $450 for 30 capsules without any discounts or insurance applied. [ 178 ]
Progesterone is a progestogen, or an agonist of the nuclear progesterone receptors (PRs), the PR-A, PR-B, and PR-C. [1] In one study, progesterone showed EC 50 Tooltip half-maximal effective concentration values of 7.7 nM for the human PR-A and 8.0 nM for the human PR-B. [5] In addition to the PRs, progesterone is an agonist of the membrane progesterone receptors (mPRs), including the mPRα ...
Binding: PR Tooltip Progesterone receptor: Promegestone = 100%. AR Tooltip Androgen receptor: Metribolone = 100%. ER Tooltip estrogen receptor: Estradiol = 100%. GR Tooltip Glucocorticoid receptor: Dexamethasone = 100%. MR Tooltip Mineralocorticoid receptor: Aldosterone = 100%. SHBG Tooltip Sex hormone-binding globulin: DHT = 100%.
0.5–1.5 mg every 2–3 days Estriol: Ovestin [c] Estrogen: Oral: 4–6 mg/day Spironolactone: Aldactone: Antiandrogen: Oral: 100–400 mg/day Cyproterone acetate: Androcur: Antiandrogen; Progestogen: Oral: 5–100 mg/day Androcur Depot: IM: 300 mg/month Bicalutamide: Casodex: Antiandrogen: Oral: 25–50 mg/day Enzalutamide: Xtandi ...
Oral potencies of progestogens [data 1]; Compound Doses for specific uses (mg/day) [a] OID TFD MDT BCPD ECD; Cycle Daily Allylestrenol: 25: 150–300 – 30 – – Bromoketoprogesterone [b]
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Ranked at No. 20 on the 2020 Disruptor 50 list. - CNBC