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Corynebacterium diphtheriae [a] is a Gram-positive pathogenic bacterium that causes diphtheria. [2] It is also known as the Klebs–Löffler bacillus because it was discovered in 1884 by German bacteriologists Edwin Klebs (1834–1912) and Friedrich Löffler (1852–1915). [3]
Corynebacterium (/ k ɔː ˈ r aɪ n ə b æ k ˌ t ɪər i ə m,-ˈ r ɪ n-/) is a genus of Gram-positive bacteria and most are aerobic.They are bacilli (rod-shaped), and in some phases of life they are, more specifically, club-shaped, which inspired the genus name (coryneform means "club-shaped").
Corynebacterium ulcerans is a rod-shaped, aerobic, and Gram-positive bacterium. Most Corynebacterium species are harmless, but some cause serious illness in humans, especially in immunocompromised humans. C. ulcerans has been known to cause diphtheria and diphtheria-like infections in patients.
In gram-positive bacteria, the S-layer is attached to the peptidoglycan layer. Gram-negative bacteria's S-layer is attached directly to the outer membrane. Specific to gram-positive bacteria is the presence of teichoic acids in the cell wall. Some of these are lipoteichoic acids, which have a lipid component in the cell membrane that can assist ...
The genera Corynebacterium [9] and Coccobacillus [10] have been designated as a pleomorphic genera, diphtheroid Bacilli have been classified as pleomorphic nosocomial bacteria. [11] Additionally, in one study focused on agents involved in a non-infectious disease, pleomorphic bacteria were found to exist in the blood of healthy human subjects. [12]
Diphtheria is an infection caused by the bacterium Corynebacterium diphtheriae. [2] Most infections are asymptomatic or have a mild clinical course, but in some outbreaks, the mortality rate approaches 10%. [1]
The Bacillaceae are a family of gram-positive, heterotrophic, rod-shaped bacteria that may produce endospores. [1] Motile members of this family are characterized by peritrichous flagella. Some Bacillaceae are aerobic, while others are facultative or strict anaerobes. Most are not pathogenic, but Bacillus species are known to cause disease in ...
Another way to diagnose BV that is less often used in a clinical setting is a Nugent score. To obtain a Nugent score, gram stain techniques are carried out and it characterizes the bacterial morphology on a scale. A score greater than 7 is associated with BV, 4-6 is an intermediate abnormality, and 0-3 is normal. [42]