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Physiologically, fibrosis acts to deposit connective tissue, which can interfere with or totally inhibit the normal architecture and function of the underlying organ or tissue. Fibrosis can be used to describe the pathological state of excess deposition of fibrous tissue, as well as the process of connective tissue deposition in healing. [ 3 ]
There is excessive scar tissue formation within the joint and/or surrounding soft tissues leading to painful restriction of joint motion that persists despite physical therapy and rehabilitation. The scar tissue may be located inside the knee joint or may involve the soft tissue structures around the knee joint, or both locations.
[3] [17] The inflammation can lead to the formation of scar tissue and adhesion that can make the spinal nerves "stick" together, a condition where such tissue develops in and between the leptomeninges - between dura and arachnoid or pia and arachnoid. [17] This condition can be very painful, especially when progressing to adhesive arachnoiditis.
The filum terminale is situated centrally [2] amid the spinal nerve roots of the cauda equina [3] [2] (but is not itself a part of the cauda equina [2]).. The inferior-most spinal nerve, the coccygeal nerve, leaves the spinal cord at the level of the conus medullaris via respective vertebrae through their intervertebral foramina, superior to the filum terminale.
Scar tissue is composed of the same protein as the tissue that it replaces, but the fiber composition of the protein is different; instead of a random basketweave formation of the collagen fibers found in normal tissue, in fibrosis the collagen cross-links and forms a pronounced alignment in a single direction. [1]
In cases like this, the body will form a scar in the area using a special type of cartilage called fibrocartilage. [2] Fibrocartilage is a tough, dense, and fibrous material that helps fill in the torn part of the cartilage; however, it is not an ideal replacement for the smooth, glassy articular cartilage that normally covers the surface of ...
Wound healing refers to a living organism's replacement of destroyed or damaged tissue by newly produced tissue. [1] In undamaged skin, the epidermis (surface, epithelial layer) and dermis (deeper, connective layer) form a protective barrier against the external environment. When the barrier is broken, a regulated sequence of biochemical events ...
Clavus papillari – a painful corn surrounded by a white border, which is either bruised or gelatinous tissue Clavus neurofibrosus (or fibrosus) – an old, deep scarred corn (in a crater with a white, sometimes macerated border) that is traversed by nerves and connective tissue, thought to be scar tissue caused by chronic low-grade inflammation.