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View of left entorhinal cortex (red) from beneath the brain, with front of brain at top. Artist's rendering. The superficial layers – layers II and III – of EC project to the dentate gyrus and hippocampus: Layer II projects primarily to dentate gyrus and hippocampal region CA3; layer III projects primarily to hippocampal region CA1 and the subiculum.
The entorhinal cortex (EC) is a major part of the hippocampal formation of the brain, and is reciprocally connected with the hippocampus. [1]The hippocampal formation, which consists of the hippocampus, perirhinal cortex, the dentate gyrus, the subicular areas and the EC forms one of the most important parts of the limbic system.
The entorhinal cortex (EC) is a structure in the brain located in the medial temporal lobe.The EC is composed of six distinct layers. The superficial (outer) layers, which include layers I through III, are mainly input layers that receive signals from other parts of the EC, but also project to hippocampal structures via the perforant path.
In mice, the projection to CA1, and the subiculum all come primarily from EC layer III. [citation needed]According to Suh et al. (2011 Science 334:1415) the projection to CA3 and dentate gyrus in mice is primarily from layer II of entorhinal cortex, and forms a trisynaptic path with hippocampus (dentate gyrus to CA3 to CA1), distinguished from the direct (monosynaptic) perforant path from ...
There is no consensus concerning which brain regions are encompassed by the term, with some authors defining it as the dentate gyrus, the hippocampus proper and the subiculum; [2] and others including also the presubiculum, parasubiculum, and entorhinal cortex. [3]
HD cells are found in many brain areas, including the cortical regions of postsubiculum (also known as the dorsal presubiculum), retrosplenial cortex, [10] and entorhinal cortex, [11] and subcortical regions including the thalamus (the anterior dorsal [12] and the lateral dorsal [13] thalamic nuclei), lateral mammillary nucleus, [14] dorsal ...
The parahippocampal gyrus (or hippocampal gyrus [1]) is a grey matter cortical region of the brain that surrounds the hippocampus and is part of the limbic system. The region plays an important role in memory encoding and retrieval. It has been involved in some cases of hippocampal sclerosis. [2] Asymmetry has been observed in schizophrenia. [3]
Thus, the hippocampus serves as the gatekeeper for information flow from the prefrontal cortex to the nucleus accumbens, such that its action permissively gates these synapses. Synaptic gating involves a variety of mechanisms by which the efficacy of neuronal activity is modulated.