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PCBs collect in body fat and milk fat. [56] PCBs biomagnify up the food web and are present in fish and overflow of contaminated aquifers. [57] Human infants are exposed to PCBs through breast milk or by intrauterine exposure through transplacental transfer of PCBs [56] and are at the top of the food chain. [58]: 249ff
Ortho-PCBs may alter hormone regulation through disruption of the thyroid hormone transport by binding to transthyretin. [8] Coplanar PCBs are similar to dioxins and furans, both bind to the aryl hydrocarbon receptor (AhR) in organisms and may exert dioxin-like effects, in addition to the effects shared with non-coplanar PCBs.
Exposure to the coplanar stereoisomer 3,3',4,4',5,5'-hexabromobiphenyl (but not the non-coplanar stereoisomer) in genetically susceptible mice is known to cause immunotoxicity and disorders related to the central nervous system, and even at doses as low as 2.5 mg/kg, excess neonatal fatalities are observed (LD 50 is from 5–10 mg/kg). [1]
The human diet accounts for over 95% of the total uptake of TEQ. [12] Risks in humans are typically calculated from known ingestion of contaminants or from blood or adipose tissue samples. However, human intake data is limited, and calculations from blood and tissue are not well supported.
PCBs are toxic to fish at high doses, and associated with spawning failure at low doses. Human exposure occurs through food, and is associated with reproductive failure and immune suppression. Immediate effects of PCB exposure include pigmentation of nails and mucous membranes and swelling of the eyelids, along with fatigue, nausea, and vomiting.
Nov. 13, 2023: An additional lab, SGS Galson, received samples of the air in Poe Hall. The company reported the results to NC State on Nov. 14. The results did not appear to indicate ...
Polychlorinated biphenyls (PCBs), derived from biphenyl, of which 12 are "dioxin-like". Under certain conditions PCBs may form dibenzofurans through partial oxidation. Polybrominated analogs of the above classes may have similar effects. "Dioxin" can also refer to 1,4-dioxin or p-dioxin, the basic chemical unit of the more complex dioxins. This ...
The Phase II study met its primary endpoints change from baseline in body weight compared to placebo across all dose tests. And the highest dose of evaluated, sought improvements for baseline in ...