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Selman Abraham Waksman (July 22, 1888 – August 16, 1973) was a Jewish American inventor, Nobel Prize laureate, biochemist and microbiologist whose research into the decomposition of organisms that live in soil enabled the discovery of streptomycin and several other antibiotics.
In the afternoon of 19 October, Schatz noticed that the tuberculosis bacteria were killed by his actinomycete extract, which he gave the name "streptomycin" [6] following the scientific name of the source and the earlier antibiotic streptothricin discovered by Waksman and H. Boyd Woodruff in 1942. [15]
[5] [6] Bugie was told that it was not important for her name to be on the patent as she would "one day get married and have a family". [1] [7] Waksman went on to win the Nobel Prize for Medicine in 1952 and took all the credit for the discovery of streptomycin. [1] Waksman claimed that Bugie was more involved in the discovery than Schatz. [8]
Streptomycin is an antibiotic medication used to treat a number of bacterial infections, [3] including tuberculosis, Mycobacterium avium complex, endocarditis, brucellosis, Burkholderia infection, plague, tularemia, and rat bite fever. [3] For active tuberculosis it is often given together with isoniazid, rifampicin, and pyrazinamide. [4]
The name was changed in 1948 by Waksman and Henrici to Streptomyces griseus. The interest in these strains stems from their ability to produce streptomycin, a compound which demonstrated significant bactericidal activity against organisms such as Yersinia pestis (the causative agent of plague) and Mycobacterium tuberculosis (the causative agent ...
Streptomycin is the first-in-class aminoglycoside antibiotic. It is derived from Streptomyces griseus and is the earliest modern agent used against tuberculosis. Streptomycin lacks the common 2-deoxystreptamine moiety (image right, below) present in most other members of this class.
Streptomyces antibioticus was discovered by Selman Waksman and H. Boyd Woodruff, who named the bacterium Actinomyces antibioticus. [2] In their 1941 publication, Waksman and Woodruff describe their use of the "bacterial-agar plate method", in which they mixed a suspension of E. coli with washed agar containing 1.5% NaCl and 0.5% K 3 PO 4. [2]
The first members of the tetracycline group to be described were chlortetracycline and oxytetracycline. [ 2 ] [ 40 ] Chlortetracycline (Aureomycin) was first discovered as an ordinary item in 1945 and initially endorsed in 1948 [ 41 ] by Benjamin Minge Duggar , a 73-year-old emeritus professor of botany employed by American Cyanamid – Lederle ...