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Sepsis is a potentially life-threatening condition that arises when the body's response to infection causes injury to its own tissues and organs. [4] [7] This initial stage of sepsis is followed by suppression of the immune system. [8] Common signs and symptoms include fever, increased heart rate, increased breathing rate, and confusion. [1]
Septic shock is a result of a systemic response to infection or multiple infectious causes. The precipitating infections that may lead to septic shock if severe enough include but are not limited to appendicitis, pneumonia, bacteremia, diverticulitis, pyelonephritis, meningitis, pancreatitis, necrotizing fasciitis, MRSA and mesenteric ischemia.
Both SIRS and sepsis could ultimately progress to multiple organ dysfunction syndrome. In one-third of the patients, however, no primary focus can be found. [1] Multiple organ dysfunction syndrome is well established as the final stage of a continuum: SIRS + infection → sepsis → severe sepsis → Multiple organ dysfunction syndrome.
Sepsis can cause a drop in body temperature and severe shivering, which is one of a response to fighting infection, and is the body’s way of trying to increase its temperature. 3. Confusion
Distributive shock is a medical condition in which abnormal distribution of blood flow in the smallest blood vessels results in inadequate supply of blood to the body's tissues and organs. [ 1 ] [ 2 ] It is one of four categories of shock , a condition where there is not enough oxygen -carrying blood to meet the metabolic needs of the cells ...
In immunology, systemic inflammatory response syndrome (SIRS) is an inflammatory state affecting the whole body. [1] It is the body's response to an infectious or noninfectious insult. Although the definition of SIRS refers to it as an "inflammatory" response, it actually has pro- and anti-inflammatory components.
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The abdomen, the central nervous system, and the organs (including the lungs) are typically spared, but the extravasation in the extremities is sufficiently massive to cause circulatory shock and compartment syndromes, with a dangerous hypotension (low blood pressure), hemoconcentration (thickening of the blood) and hypoalbuminemia (drop in ...