Search results
Results from the WOW.Com Content Network
Nevertheless, falsely increased PT has been reported, likely by lupus anticoagulant interfering with the phospholipid component of the PT reagent, particularly when using recombinant tissue factor and purified phospholipids. [10] A mixing test is generally in the initial workup of a prolonged aPTT. In a mixing test, patient plasma is mixed with ...
The partial thromboplastin time (PTT), also known as the activated partial thromboplastin time (aPTT or APTT), is a blood test that characterizes coagulation of the blood.A historical name for this measure is the Kaolin-cephalin clotting time (KCCT), [1] reflecting kaolin and cephalin as materials historically used in the test.
The basic purpose of these tests is to determine the cause of prolongation of Prothrombin Time (PT), Partial Thromboplastin Time, or sometimes of thrombin time (TT). Mixing studies take advantage of the fact that factor levels that are 50 percent of normal should give a normal Prothrombin time (PT) or Partial thromboplastin time (PTT) result. [2]
The prothrombin time can be prolonged as a result of deficiencies in vitamin K, warfarin therapy, malabsorption, or lack of intestinal colonization by bacteria (such as in newborns). In addition, poor factor VII synthesis (due to liver disease) or increased consumption (in disseminated intravascular coagulation) may prolong the PT. [citation ...
Clotting time is a general term for the time required for a sample of blood to form a clot, or, in medical terms, coagulate.The term "clotting time" is often used when referring to tests such as the prothrombin time (PT), activated partial thromboplastin time (aPTT or PTT), activated clotting time (ACT), thrombin time (TT), or Reptilase time.
Typical is a discordance between the prolonged prothrombin time (PT) and normal levels for the activated partial thromboplastin time (APTT). [1] FVII levels are <10IU/dl in homozygous individuals, and between 20-60 in heterozygous carriers. [2] The FCVII: C assay supports the diagnosis. [1] The FVII gene (F7) is found on chromosome 13q34. [1]
Partial thromboplastin time, activated partial thromboplastin time, thrombin time, and reptilase time tests are usually prolonged regardless of history of bleeding or thrombosis. [11] Where available, laboratory analyses of the fibrinogen genes and peptide chains solidify the diagnosis.
The condition is diagnosed by blood tests in the laboratory when it is noted that special blood clotting test are abnormal. Specifically Activated Partial Thromboplastin Time (aptt) is prolonged. [2] The diagnosis is confirmed by an assay detecting very low or absent FXII levels. [citation needed] The FXII (F12) gene is found on chromosome 5q33 ...