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2-Chloromethylpyridine is an organohalide that consists of a pyridine core bearing a chloromethyl group. It is one of three isomeric chloromethylpyridines, along with 3- and 4-chloromethylpyridine. It is an alkylating agent . 2-Chloromethylpyridine is a precursor to pyridine-containing ligands .
Heating the reaction intermediate with 2-chloro-5-(chloromethyl)pyridine in THF under reflux yields flupyradifurone. [2] In the second method, tetronic acid, 4-touluenesulfonic acid, and N-[(6-chloropyridin-3-yl)methyl]-2,2-difluoroethane-1-amine in toluene are heated under reflux for 2 hours to produce flupyradifurone. [2]
In these conversions, chloride is displaced. [2] Pyrithione, the conjugate base of 2-mercaptopyridine-N-oxide, is a fungicide found in some shampoos. Oxidation 2-chloropyridine gives 2-chloropyridine-N-oxide. [5] The antihistamine pheniramine may be generated via the reaction of phenylacetonitrile with 2-chloropyridine in the presence of a base ...
Structure of the chloromethyl group. In organic chemistry, the chloromethyl group is a functional group that has the chemical formula −CH 2 −Cl. The naming of this group is derived from the methyl group (which has the formula −CH 3), by replacing one hydrogen atom by a chlorine atom. Compounds with this group are a subclass of the ...
Direct halogenation of pyridine with chlorine gas above 270 °C gives a mixture of 2-chloropyridine and 2,6-dichloropyridine. [1] 2- and 4-chloropyridine are prepared from the corresponding pyridinols using phosphoryl chloride. [1]
Chloro(pyridine)cobaloxime(III) is first reduced to Chloro(pyridine)cobaloxime(I) by sodium borohydride in alkaline solution, then an alkyl halide is added into the reaction mixture, and the desired Co-C bond is formed via a S N 2 reaction. This method can be used to produce cobaloximes containing a primary or a secondary alkyl substituent.
2-Mercaptopyridine was originally synthesized in 1931 by heating 2-chloropyridine with calcium hydrogen sulfide. [2]ClC 5 H 4 N + Ca(SH) 2 → HSC 5 H 4 N + Ca(SH)Cl. A more convenient route to 2-mercaptopyridine is the reaction of 2-chloropyridine and thiourea in ethanol and aqueous ammonia.
In the minor reaction pathway, a Prilezhaev epoxidation [14] results in the formation of thiophene-2,3-epoxide that rapidly rearranges to the isomer thiophene-2-one. [12] Trapping experiments [ 15 ] demonstrate that this pathway is not a side reaction from the S -oxide intermediate, while isotopic labeling with deuterium confirm that a 1,2 ...