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A crista (/ ˈ k r ɪ s t ə /; pl.: cristae) is a fold in the inner membrane of a mitochondrion. The name is from the Latin for crest or plume , and it gives the inner membrane its characteristic wrinkled shape, providing a large amount of surface area for chemical reactions to occur on.
In the mitochondrion, the matrix is the space within the inner membrane. The word "matrix" stems from the fact that this space is viscous, compared to the relatively aqueous cytoplasm. The mitochondrial matrix contains the mitochondrial DNA, ribosomes, soluble enzymes, small organic molecules, nucleotide cofactors, and inorganic ions. [1]
This ratio is variable and mitochondria from cells that have a greater demand for ATP, such as muscle cells, contain even more cristae. Cristae membranes are studded on the matrix side with small round protein complexes known as F 1 particles, the site of proton-gradient driven ATP synthesis. Cristae affect overall chemiosmotic function of ...
The inner mitochondrial membrane, The cristae space (formed by infoldings of the inner membrane), and; The matrix (space within the inner membrane), which is a fluid. Mitochondria have folding to increase surface area, which in turn increases ATP (adenosine triphosphate) production. Mitochondria stripped of their outer membrane are called ...
Complex III and IV are proton pumps, pumping H+ protons out of the mitochondrial matrix, and work in conjunction with complex I to create the proton gradient found at the inner membrane. Cytochrome c is and electron carrier protein that travels between complex III and IV, and triggers apoptosis if it leaves the cristae.
This part of the enzyme is located in the mitochondrial inner membrane and couples proton translocation to the rotation that causes ATP synthesis in the F 1 region. In eukaryotes, mitochondrial F O forms membrane-bending dimers. These dimers self-arrange into long rows at the end of the cristae, possibly the first step of cristae formation. [12]
Then they are transported across the inner mitochondrial membrane into the matrix and converted into the acetyl CoA to enter the citric acid cycle. [7] [8] Apoptotic components released from the intermembrane space of a mitochondrion. The respiratory chain in the inner mitochondrial membrane carries out oxidative phosphorylation.
OPA1 plays both a genetic and molecular role in mitochondrial fusion and in cristae remodeling during apoptosis. [5] OPA1 exists in two forms; the first being soluble and found in the intermembrane space, and the second as an integral inner membrane form, work together to restructure and shape the cristae during and after apoptosis.