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Over-supplementation of vitamins A and D can cause vitamin toxicity in dogs. [72] Excess vitamin A can cause dehydration , joint pain and can also harm the blood vessels , while too much vitamin D can cause muscular atrophy , loss of appetite and many other health-related problems .
It is the most commonly prescribed vitamin D metabolite for patients with end stage renal disease, given that impaired renal function alters the ability to carry out the second hydroxylation step required for the formation of the physiologically active form of vitamin D, 1,25-dihydroxyvitamin D3. Alfacalcidol is an active vitamin D3 metabolite ...
Dogs are able to synthesize and convert 7-dehydrocholesterol (provitamin form of vitamin D) to cholecalciferol (inactive form of vitamin D) following exposure to UV light from the sun. [27] Cholecalciferol is then converted to calcidiol in the liver before further hydroxylated to calcitriol, the active form of vitamin D, in the kidney. [28]
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Vitamin D is produced in the keratinocytes of two innermost strata of the epidermis, the stratum basale and stratum spinosum, which also are able to produce calcitriol and express the vitamin D receptor. [173] Vitamin D 3 is produced photochemically from 7-dehydrocholesterol in the skin of most vertebrate animals, including humans. [174]
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