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The AUC (area under the curve) of the ROC curve reflects the overall accuracy and the separation performance of the biomarker (or biomarkers), [3] and can be readily used to compare different biomarker combinations or models. [4] As a rule of thumb, the fewer the biomarkers that one uses to maximize the AUC of the ROC curve, the better.
In biomedical contexts, a biomarker, or biological marker, is a measurable indicator of some biological state or condition. Biomarkers are often measured and evaluated using blood, urine, or soft tissues [1] to examine normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention. [2]
In medicine, a biomarker is a measurable indicator of the severity or presence of some disease state. It may be defined as a "cellular, biochemical or molecular alteration in cells, tissues or fluids that can be measured and evaluated to indicate normal biological processes, pathogenic processes, or pharmacological responses to a therapeutic intervention."
Prognostic markers are biomarkers used to measure the progress of a disease in the patient sample. [1] Prognostic markers are useful to stratify the patients into groups, guiding towards precise medicine discovery. The widely used prognostic markers in cancers include stage, size, grade, node and metastasis. In addition to these common markers ...
Download as PDF; Printable version; In other projects Wikiversity; Wikidata item; ... Pages in category "Biomarkers" The following 82 pages are in this category, out ...
Cardiac markers are biomarkers measured to evaluate heart function. They can be useful in the early prediction or diagnosis of disease. [1] Although they are often discussed in the context of myocardial infarction, other conditions can lead to an elevation in cardiac marker level.
It is intended to be used for applications in metabolomics, clinical chemistry, biomarker discovery and general education. The database is designed to contain or link three kinds of data: Chemical data, Clinical data and; Molecular biology/biochemistry data.
Biomarkers and biomarker signature combinations, are useful for determining disease states [3] and drug efficacy. [4] Most methods for detecting proteins involve the use of a solid phase for first capturing and immobilizing the protein analyte, where in one or a few proteins are quantified, such as ELISA .