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Elephant endotheliotropic herpesviruses (EEHV) or Elephantid betaherpesvirus 1 (ElHV-1) is a type of herpesvirus, which can cause a highly fatal hemorrhagic disease when transmitted to young Asian elephants. In African elephants, related forms of these viruses, which have been identified in wild populations, are generally benign, occasionally ...
In October 2022, Colossal announced that it was developing a vaccine for elephant endotheliotropic herpesvirus (EEHV), in partnership with the Baylor College of Medicine. [50] In May 2023, Colossal partnered with the Vertebrate Genomes Project to successfully generate the first high-quality reference genome of an African elephant. This ...
EEHV is the single largest cause of death for juvenile Asian elephants in North America and Europe. Furthermore, EEHV-associated deaths have been documented in wild elephants in their natural range countries in both Africa and Asia, adding yet another threat to these endangered species.
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Proboscivirus is located under the listings of the ICTV Updates as Section §2005.049-050V.04. [4] With the creation of Proboscivirus as a new genus came the creation and categorization of a new species under this genus, by the name of Elephantid betaherpesvirus 1 (Acronym: EEHV1 and Scientific Name: Elephant endotheliotropic herpesvirus) [5] under ICTV §2005.051-050V.04.
In North America, EEHV has been responsible for 58% of the deaths of Asian elephants in captivity between the ages of 4 months and 15 years that were born between 1962 and 2007. [42] EEHV has also caused the death of Asian elephant calves in captivity in Europe [43] and Asia, [44] as well as wild calves. [45]
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Elephants may also be host for a variety of parasites and bacteria such as Pasteurella, [86] Salmonella, Clostridium, [87] coccidian, nematode, and trematode. [88] The elephant endotheliotropic herpesvirus (EEHV) is a member of the Proboscivirus genus, a novel clade most closely related to the mammalian betaherpesviruses. [89]