Search results
Results from the WOW.Com Content Network
Like many other medical conditions, obesity is the result of an interplay between environmental and genetic factors. [2] [3] Studies have identified variants in several genes that may contribute to weight gain and body fat distribution, although only in a few cases are genes the primary cause of obesity.
The dual intervention point model posits that rather than a body weight set point, there is a set range for body weight. Under this model, active compensation happens only outside of upper and lower intervention points, and for weights within the set range, environmental factors would have a strong effect on body weight since there would only ...
The extreme endpoint of this distribution are the so-called 'monogenic' obesities where most of the impact on body weight can be tied to a mutation in a single gene that runs in a single family. The classic example of such a genetic effect is the presence of mutations in the leptin gene.
[22] [96] [178] [179] Although it is unclear what diets might support long-term weight loss, and although the effectiveness of low-calorie diets is debated, [180] lifestyle changes that reduce calorie consumption or increase physical exercise over the long term also tend to produce some sustained weight loss, despite slow weight regain over time.
Gene–environment correlations (or rGE) is correlation of two traits, e.g. height and weight, which would mean that when one changes, so does the other. Gene–environment correlations can arise by both causal and non-causal mechanisms. [1] Of principal interest are those causal mechanisms which indicate genetic control over environmental ...
Learning which variations influence which specific traits and how strongly they do so, are the key targets for constructing polygenic scores in humans. The methods were first considered for humans after the year 2000, and specifically by a proposal in 2007 that such scores could be used in human genetics to identify individuals at high risk for ...
Upgrade to a faster, more secure version of a supported browser. It's free and it only takes a few moments:
To support the hypothesis that core genes play a smaller than expected role, the authors describe three main observations: the heritability for complex traits is spread broadly, often uniformly, across the genome; genetic effects do not appear to be mediated by cell-type specific function; and genes in the relevant functional categories only ...