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In the 1960s and 1970s, John Vane and others discovered the basic mechanism of aspirin's effects, [3]: 226–231 while clinical trials and other studies from the 1960s to the 1980s established aspirin's efficacy as an anti-clotting agent that reduces the risk of clotting diseases.
Aspirin is the genericized trademark for acetylsalicylic acid ... In the 1960s and 1970s, John Vane and others discovered the basic mechanism of aspirin's effects, ...
He had discovered salicylic acid, the principal metabolite of aspirin. On 25 April 1763, he sent a letter announcing his discovery to George Parker, 2nd Earl of Macclesfield , President of the Royal Society .
Acetylsalicylic acid (Aspirin) 1899 1875: Phenylhydrazine: Hermann Emil Fischer: 1875 1875: 1877: ... Discovered by Henry Hallett Dale, synthesized by Vincent du ...
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Sir John Robert Vane FRS (29 March 1927 – 19 November 2004) [1] was a British pharmacologist who was instrumental in the understanding of how aspirin produces pain-relief and anti-inflammatory effects and his work led to new treatments for heart and blood vessel disease and introduction of ACE inhibitors.
Salicylic acid has long been a key starting material for making acetylsalicylic acid (ASA or aspirin). [8] ASA is prepared by the acetylation of salicylic acid with the acetyl group from acetic anhydride or acetyl chloride. [17] ASA is the standard to which all the other non-steroidal anti-inflammatory drugs are compared. In veterinary medicine ...
Felix Hoffmann (21 January 1868 – 8 February 1946) was a German chemist notable for re-synthesising diamorphine (independently from C.R. Alder Wright who synthesized it 23 years earlier), which was popularized under the Bayer trade name of "heroin".