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One may also develop drug tolerance to side effects, [7] in which case tolerance is a desirable characteristic. A medical intervention that has an objective to increase tolerance (e.g., allergen immunotherapy, in which one is exposed to larger and larger amounts of allergen to decrease one's allergic reactions) is called drug desensitization. [8]
Tolerability, however, is often relative to the severity of the medical condition a drug is designed to treat. [1] For instance, cancer patients may tolerate significant pain or discomfort during a chemotherapeutic study with the hope of prolonging survival or finding a cure, whereas patients experiencing a benign condition, such as a headache ...
LOPA is a risk assessment undertaken on a 'one cause–one consequence' pair. The steps of a LOPA risk assessment are: [4] Identify the consequences, using a risk matrix; Define the risk tolerance criteria (RTC), based on the tolerable/intolerable regions on the risk matrix; Define the relevant accident scenario, e.g. mechanical or human failure
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Should the risk assessment establish that the required SIL cannot be achieved by a SIL4 SIF, then alternative arrangements must be designed, such as non-instrumented safeguards (e.g, a pressure relief valve). [1] There are several methods used to assign a SIL. These are normally used in combination, and may include: [1] Risk matrices; Risk graphs
Risk homeostasis is a controversial hypothesis, initially proposed in 1982 by Gerald J. S. Wilde, a professor at Queen's University in Canada, which suggests that people maximise their benefit by comparing the expected costs and benefits of safer and riskier behaviour and which introduced the idea of the target level of risk.
Generally, >7 METs of activity tolerance is considered excellent while <4 is considered poor for surgical candidates. Determining one's functional capacity can elucidate the degree of surgical risk one might undertake for procedures that risk blood loss, intravascular fluid shifts, etc. and may tax an already strained cardiovascular system. [5]