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Nystatin may be used by mouth, in the vagina, or applied to the skin. [1] Common side effects when applied to the skin include burning, itching, and a rash. [1] Common side effects when taken by mouth include vomiting and diarrhea. [1] During pregnancy use in the vagina is safe while other formulations have not been studied in this group. [1]
Topical antifungal drugs are used to treat fungal infections on the skin, scalp, nails, vagina or inside the mouth. These medications come as creams, gels, lotions, ointments, powders, shampoos, tinctures and sprays. Most antifungal drugs induce fungal cell death by destroying the cell wall of the fungus.
Fluconazole is an antifungal medication used for a number of fungal infections. [5] This includes candidiasis, blastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, dermatophytosis, and tinea versicolor. [5]
Clotrimazole is an imidazole derivative that works by inhibiting the growth of individual Candida or fungal cells by altering the permeability of the fungal cell wall. [7] The drug impairs the biosynthesis of ergosterol , a critical component of the fungal cell membrane, by inhibiting the P450 enzyme lanosterol 14-alpha demethylase. [ 19 ]
Ketoconazole, sold under the brand name Nizoral, among others, is an antiandrogen, antifungal, and antiglucocorticoid medication used to treat a number of fungal infections. [11] Applied to the skin it is used for fungal skin infections such as tinea, cutaneous candidiasis, pityriasis versicolor, dandruff, and seborrheic dermatitis. [12]
Tolnaftate [1] sold under the brand name TAGRID among, others is a synthetic thiocarbamate used as an anti-fungal agent that may be sold without medical prescription in most jurisdictions. It is supplied as a cream, powder, spray, liquid, and liquid aerosol . [ 2 ]
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