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5-MeO-isoDMT, or 5-OMe-isoDMT, also known as 5-methoxy-N,N-dimethylisotryptamine, is a putatively non-hallucinogenic serotonin 5-HT 2A receptor agonist and psychoplastogen of the isotryptamine group.
5-MeO-EPT is illegal in Singapore [3] and Japan, [4] as well as falling within the scope of drug analogue laws in a number of other jurisdictions. See also [ edit ]
[1] [2] [4] [6] However, isoDMT retains significant activity at the serotonin 5-HT 2 receptors and shows psychoplastogenic effects comparable to those of serotonergic psychedelics in preclinical research. [7] [6] [8] [9] Its affinities (K i) for the serotonin 5-HT 2 receptors have been reported to be 600–650 nM for 5-HT 2A and 720 nM at 5-HT ...
5-Methoxy-N-propyl-N-isopropyltryptamine (5-MeO-PiPT) is a substituted tryptamine derivative which is claimed to have psychedelic effects. It acts as a 5-HT 1A and 5-HT 2A receptor agonist, [ 1 ] with an EC 50 of 13.8 nM and an efficacy of 89% (vs 5-HT), [ 2 ] and has been sold as a designer drug , first being identified in 2021 in British ...
5,N-Dimethyl-N-isopropyltryptamine (5-Me-MiPT) is a tryptamine derivative that is thought to be a psychedelic drug.It was first made in 1989. In vitro binding experiments on brain homogenates showed it to have serotonin receptor binding affinity between that of MiPT and 5-MeO-MiPT, [1] both of which are known to be active psychedelics in humans.
5-MeO-MALT (5-methoxy-N-methyl-N-allyltryptamine) is a lesser-known psychedelic drug [1] that is closely related to 5-MeO-DALT and has been sold online as a designer drug. [ 2 ] [ 3 ] Legality
5-MeO-DBT (5-Methoxy-N,N-dibutyltryptamine, 5-MeO-BET) is a rare substituted tryptamine derivative, which is thought to be a psychoactive substance and was identified in a designer drug sample by a forensic laboratory in Slovenia in March 2021, [1] although only analytical studies have been conducted and no pharmacological data is available.
The widespread recreational use of N,N-dialkylated 5-methoxytryptamine derivatives including 5-MeO-DMT, 5-MeO-MiPT and 5-MeO-DiPT has led to concern that the 5-ethoxy homologs of these drugs could emerge as novel designer drugs, and consequently 5-EtO-DMT and other derivatives including 5-EtO-DET, 5-EtO-DPT, 5-EtO-DiPT, 5-EtO-DALT, 5-EtO-MPT, 5 ...