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Serum vitamin B 12 is a medical laboratory test that measure vitamin B 12 only in the blood binding to both transcobalamins. [1] Most of the time, 80–94% of vitamin B 12 in the blood binds to haptocorrin, while only 6–20% is binds to transcobalamin ll. [2] Only transcobalamin ll is "active" and can be used by the body. [1]
For this reason, elevated serum homocysteine over 15 micromol/L and methylmalonic acid (MMA) over 0.271 micromol/L are considered better indicators of B 12 deficiency, rather than relying only on the concentration of B 12 in blood. [2] However, elevated MMA is not conclusive, as it is seen in people with B 12 deficiency, but also in elderly ...
Haptocorrin (HC) also known as transcobalamin-1 (TC-1) or cobalophilin is a transcobalamin protein that in humans is encoded by the TCN1 gene. [3] One essential function of haptocorrin is protection of the acid-sensitive vitamin B 12 while it moves through the stomach.
Registered dietitians explain what vitamin B12 is, how much you need, and the potential side effects of taking too much. Skip to main content. 24/7 Help. For premium support please call: ...
A vitamin B12 level of less than 200 pg/mL is considered deficient. Treatment First, have your health care provider run blood tests to see if you truly have a B12 deficiency.
Hyperhomocysteinemia is a medical condition characterized by an abnormally high level of total homocysteine (that is, including homocystine and homocysteine-cysteine disulfide) in the blood, conventionally described as above 15 μmol/L. [1]
TC-2 binds cobalamin once it has been taken up by enterocytes of the terminal ileum and the "Intrinsic Factor-Vitamin B12" complex has been degraded. TC-2 is then involved with the transport of Vitamin B12 to the tissues, where it binds to its plasma membrane receptor (TC-2R), a heavily glycosylated protein with a monomeric molecular mass of 62 ...
Vitamin B12, also known as cobalamin, isn’t just a popular supplement marketed to help people lose weight— it’s an essential water-soluble vitamin necessary for brain function, heart health ...