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Drugs of abuse increase the VTA's ability to project dopamine to the rest of the reward circuit. [6] These structural changes only last 7–10 days, [ 7 ] however, indicating that the VTA cannot be the only part of the brain that is affected by drug use, and changed during the development of addiction.
The effects of psychedelics on neuroplasticity appear to be dependent on serotonin 5-HT 2A receptor activation, as they are abolished in 5-HT 2A receptor knockout mice. [7] Non-hallucinogenic serotonin 5-HT 2A receptor agonists, like tabernanthalog and lisuride, have also been found to increase neuroplasticity, and to a magnitude comparable to ...
Innovative treatments are still needed for areas where relevant therapies are unavailable. [4] Consistent aerobic exercise, especially endurance exercise (e.g., marathon running), prevents the development of certain drug addictions and is an effective adjunct treatment for drug addiction, and for psychostimulant addiction in particular.
A new study from the Novo Nordisk Foundation Center for Basic Metabolic Research at the University of Copenhagen used GLP-1 drugs as a "Trojan horse" to increase neuroplasticity in the brain ...
GLP-1 drugs such as Wegovy and Ozempic (semaglutide) and Zepbound (tirzepatide) may offer benefits that extend beyond aiding in weight loss in people who have type 2 diabetes or obesity.
The subsequent increase in both synaptic excitation and neuroplasticity is believed to precipitate the powerful and immediate symptom reduction ketamine elicits for a variety of conditions. It has additionally been theorized that ketamine disrupts the reconsolidation of dysfunctional memories and, through doing so, diminishes the burden of ...
One recent study of neuroplasticity involves work done by a team of doctors and researchers at Emory University, specifically Donald Stein [149] and David Wright. This is the first treatment in 40 years that has significant results in treating traumatic brain injuries while also incurring no known side effects and being cheap to administer. [69]
Stigmatization of drug use, the War on Drugs and criminalization, and the social determinants of health should all be considered when discussing access to drug treatment and potential barriers. Broad categories of barriers to drug treatment are: absences of problem, negative social support, fear of treatment, privacy concerns, time conflict ...