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Cevimeline is a cholinergic agonist. [2] It has a particular effect on M 1 and M 3 receptors . [ 2 ] By activating the M 3 receptors of the parasympathetic nervous system , cevimeline stimulates secretion by the salivary glands , thereby alleviating dry mouth.
Pilocarpine is a drug that acts as a muscarinic receptor agonist that is used to treat glaucoma Cevimeline (AF102B) (Evoxac®) is a muscarinic agonist that is a Food and Drug Administration (FDA)- approved drug and used for the management of dry mouth in Sjögren's syndrome
Pilocarpine is in the miotics family of medication. [11] It works by activating cholinergic receptors of the muscarinic type which cause the trabecular meshwork to open and the aqueous humor to drain from the eye. [1] Pilocarpine was isolated in 1874 by Hardy and Gerrard and has been used to treat glaucoma for more than 100 years.
Trihexyphenidyl (THP, benzhexol, trihex, marketed as Artane and others) is an antispasmodic drug used to treat stiffness, tremors, spasms, and poor muscle control. It is an agent of the antimuscarinic class and is often used in management of Parkinson's disease.
For generic names, this is the agency which has designated that name. [eg (), (), or ()]for brand names, this is the company which produces that brand. If there is more than one agency, then use a comma separated list in the brackets [eg (INN, BAN)]
Cyclopentolate is a muscarinic antagonist. [2] It is commonly used as an eye drop during pediatric eye examinations to dilate the eye and prevent the eye from focusing/accommodating (cycloplegic).
Methacholine is primarily used to diagnose bronchial hyperreactivity, [1] which is the hallmark of asthma and also occurs in chronic obstructive pulmonary disease.This is accomplished through the bronchial challenge test, or methacholine challenge, in which a subject inhales aerosolized methacholine, leading to bronchoconstriction.
Used in fixed combination with chlordiazepoxide in the treatment of functional GI motility disturbances (e.g., irritable bowel syndrome). Has limited efficacy in treatment of GI motility disturbance and should only be used if other measures (e.g., diet, sedation, counseling, amelioration of environmental factors) have been of little or no benefit.
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