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Aromatic L-amino acid decarboxylase is active as a homodimer.Before addition of the pyridoxal phosphate cofactor, the apoenzyme exists in an open conformation. Upon cofactor binding, a large structural transformation occurs as the subunits pull closer and close the active site.
An aromatic L-amino acid decarboxylase inhibitor (synonyms: DOPA decarboxylase inhibitor, extracerebral decarboxylase inhibitor, DDCI and AAADI) is a medication of type enzyme inhibitor which inhibits the synthesis of dopamine by the enzyme aromatic L-amino acid decarboxylase (AADC, AAAD, or DOPA decarboxylase).
Eladocagene exuparvovec is indicated for the treatment of aromatic L-amino acid decarboxylase (AADC) deficiency. [3]Aromatic L-amino acid decarboxylase deficiency is a rare genetic disorder that affects the production of some neurotransmitters, which are chemical messengers that allow cells in the body's nervous system to communicate with each other. [4]
Aromatic L-amino acid decarboxylase deficiency has an autosomal recessive pattern of inheritance. Aromatic L-amino acid decarboxylase deficiency is an autosomal recessive condition, meaning an individual needs to have two faulty copies of the DDC gene in order to be affected. Usually, one copy is inherited from each parent. [3]
Carbidopa inhibits aromatic L-amino-acid decarboxylase (DOPA decarboxylase or DDC), [1] an enzyme important in the biosynthesis of serotonin from L-tryptophan and in the biosynthesis of dopamine (DA) from L-DOPA. DDC exists both outside of (body periphery) and within the confines of the blood–brain barrier.
Once levodopa has entered the central nervous system, it is converted into dopamine by the enzyme aromatic l-amino acid decarboxylase (AAAD), also known as DOPA decarboxylase (DDC). Pyridoxal phosphate (vitamin B 6) is a required cofactor in this reaction, and may occasionally be administered along with levodopa, usually in the form of pyridoxine.
Droxidopa is a prodrug of norepinephrine used to increase the concentrations of these neurotransmitters in the body and brain. [4] It is metabolized by aromatic L-amino acid decarboxylase (AAAD), also known as DOPA decarboxylase (DDC).
Aromatic-L-amino-acid decarboxylase; Glutamate decarboxylase; Histidine decarboxylase; Ornithine decarboxylase; Phosphoenolpyruvate carboxylase; Pyruvate decarboxylase; RuBisCO – the only carboxylase that leads to a net fixation of carbon dioxide; Uridine monophosphate synthetase; Uroporphyrinogen III decarboxylase; enoyl-CoA carboxylases ...