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Obstructive lung diseases often result from impaired mucociliary clearance that can be associated with mucus hypersecretion and these are sometimes referred to as mucoobstructive lung diseases. [12] Studies have shown that the dehydration of airway surface liquid is enough to produce mucus obstruction even when there is no evidence of mucus ...
The cells were first noted by Henle in 1837 when studying the lining of the small intestine, seen to be mucus producing by Leydig in 1857 (who was examining the epidermis of fish), and were given their name by Schulze in 1867, [24] [25] Schulze chose the descriptive name "goblet" because of the shape of the cell, rather than a functional name ...
The cells in the respiratory epithelium are of five main types: a) ciliated cells, b) goblet cells, c) brush cells, d) airway basal cells, and e) small granule cells (NDES) [6] Goblet cells become increasingly fewer further down the respiratory tree until they are absent in the terminal bronchioles; club cells take over their role to some extent here. [7]
Mucus is a normal protective layering around the airway, eye, nasal turbinate, and urogenital tract. Mucus is an adhesive viscoelastic gel produced in the airway by submucosal glands and goblet cells and is principally water. It also contains high-molecular weight mucous glycoproteins that form linear polymers.
Mucus is made up of a fluid component of around 95% water, the mucin secretions from the goblet cells, and the submucosal glands (2–3% glycoproteins), proteoglycans (0.1–0.5%), lipids (0.3–0.5%), proteins, and DNA. [7] The major mucins secreted – MUC5AC and MUC5B - are large polymers that give the mucus its rheologic or viscoelastic ...
In humans the lungs are located in the chest on either side of the heart in the rib ... goblet cells secrete mucus ... Other lung function tests include spirometry, ...
The acini empty into little tubes (tubules) that lead to a reservoir (collecting duct) that has a portal through the skin (mucosa) that can open and close allowing the mucus into the main tube. [ 1 ] The submucosal glands are a companion to goblet cells which also produce mucus, and are found lining the same tubes.
Interleukin-13 induces goblet cell differentiation and allows for the production of MUC5AC in tracheal epithelium. [12] 15-Lipoxygenase-1 (15LO1) which is an enzyme in the fatty acid metabolism and its metabolite, 15-HETE, are highly expressed in asthma (which lead to the overexpression of MUC5AC) and are induced by IL-13 in human airway ...