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Lactobacillus is a genus of gram-positive, aerotolerant anaerobes or microaerophilic, rod-shaped, non-spore-forming bacteria. [2] [3] Until 2020, the genus Lactobacillus comprised over 260 phylogenetically, ecologically, and metabolically diverse species; a taxonomic revision of the genus assigned lactobacilli to 25 genera (see § Taxonomy below).
VMB is dominated mainly by Lactobacillus species. This is the list of organisms that are found in the lower reproductive tract of sexually mature women who are not immunocompromised . A partial description of pathogens that can be found in the lower and upper reproductive tract of women can be found in the article sexually transmitted infection .
Vaginal microbiota including some Lactobacillus species protect the vagina from harmful pathogens. [10] They convert glucose to lactic acid and this acidic environment kills harmful pathogens. The vaginal microbiota in pregnancy varies markedly during the entire time of gestation. The species and diversity of the microorganisms may be related ...
Lactobacillus jensenii is a lactic acid bacteria species in the genus Lactobacillus. It is one of the four main species of Lactobacillus considered to be the major part of the vaginal flora, along with Lactobacillus crispatus, Lactobacillus gasseri, and Lactobacillus iners. [1] [2] L. jensenii is sometimes used in producing fermented foods. [3]
The Lactobacillaceae are also the only family of the lactic acid bacteria which does not include pathogenic or opportunistic pathogenic organisms although some species, particularly Lacticaseibacillus rhamnosus and Weissella spp. can cause rare infections in critically ill patients. [5] [6]
LACTIN-V is a live biopharmaceutical medication containing the vaginally important Lactobacillus crispatus which is under development for the treatment of bacterial vaginosis and recurrent urinary tract infections. [68] [69] [70] It has shown initial effectiveness in considerably reducing recurrence of bacterial vaginosis following antibiotic ...
The inhibitory substances produced by vaginal Lactobacillus is a primary factor in protecting the vaginal microbiota, with organic acids, bacteriocins, and hydrogen peroxide. These act synergistically against infection by pathogens. Not all Lactobacillus spp. and not all strains within one Lactobacillus species exhibit all 3 mechanisms. [13]
Lactobacillus crispatus is a common, rod-shaped species of genus Lactobacillus and is a lactic acid producing bacterial species located in both the vagina, through vaginal discharge, and the vertebrate gastrointestinal tract. [1] This species commonly found in vaginal microbiome and is thought to be beneficial to health. [2]
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