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The observed probable serious effects for human health and the environment are thyroid hormonal disturbances and reproductive toxicity seen in rodents, and effects on liver, kidney and haematological system in rats, hormonal disturbances and effects on reproduction in marine medaka fish and effects on expression of hormone receptors in tadpoles.
The effects of climate change on human health are profound because they increase heat-related illnesses and deaths, respiratory diseases, and the spread of infectious diseases. There is widespread agreement among researchers, health professionals and organizations that climate change is the biggest global health threat of the 21st century. [1] [2]
Early clinical testing showed a high prevalence of respiratory health effects. Early symptoms of exposure often presented with persistent coughing and wheezing. PFOA and PFHxS levels were present in both smoke and dust exposure, but first responders exposed to smoke had higher concentrations of PFOA and PFHxS than those exposed to dust. [220]
Research on PFOA has demonstrated ubiquity, animal-based toxicity, and some associations with human health parameters and potential health effects. Additionally, advances in analytical chemistry in recent years have allowed the routine detection of low- and sub-parts per billion levels of PFOA in a variety of substances. [18]
10 January 2018 According to the U.S. Department of Health & Human Services's Agency for Toxic Substances and Disease Registry (ATSDR) website, which was last reviewed on10 January 2018, the "health effects of PFOS, PFOA, PFHxS, and PFNA have been more widely studied than other per- and polyfluoroalkyl substances (PFAS). Some, but not all ...
A number of jurisdictions have guidelines or limits for the concentration of PFHxS in water, in diets, and in the environment. There are fewer regulations on PFHxS compared to PFOS and PFOA. This reflects the relative lack of epidemiological and toxicological information on the human health effects of exposure to PFHxS. [4]
There is a growing body of research investigating the health effects of PFOS in humans and animals, including the reproductive, developmental, liver, kidney, thyroid, and immunological effects. [42] According to a 2002 report by the Environmental Directorate of the OECD , "PFOS is persistent, bioaccumulative, and toxic to mammalian species."
Examples include PFOA and PFOS, frequently present in water-resistant textiles and sprays conferring water-resistant properties to textiles and fire-fighting foam. [3] Data from animal studies of PFOA indicate that it can cause several types of tumors and neonatal death and may have toxic effects on the immune, liver, and endocrine systems.
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