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The development of stimuli-responsive drug carriers was not popularized until the mid-1980s by researchers at Utah University, who created thermally-responsive drug delivery systems. [4] Since the eruption of this field, substantial research has been conducted to tune stimuli-responsive drug delivery systems despite several limitations.
Ultrasound-triggered drug delivery using stimuli-responsive hydrogels refers to the process of using ultrasound energy for inducing drug release from hydrogels that are sensitive to acoustic stimuli. This method of approach is one of many stimuli-responsive drug delivery-based systems that has gained traction in recent years due to its ...
The most commonly used materials for stretch-triggered autonomous drug release systems are hydrogels and elastomers. [1] This method of drug delivery falls in the category of stimuli-responsive drug delivery systems which include pH, temperature, and redox-responsive systems. Mechanical forces occur naturally throughout the human body therefore ...
Self-microemulsifying drug delivery system; Shampoo; Silicone gel sheeting; Sink condition; Small molecule drug conjugate; Smoking; Softgel; Solution (chemistry) Sonophoresis; Stimuli-responsive drug delivery systems; Stretch-triggered drug delivery; Suppository; Suspension (chemistry) Modified-release dosage; Syrette; Syringe
Drug delivery systems have been around for many years, but there are a few recent applications of drug delivery that warrant 1. Drug delivery to the brain: Many drugs can be harmful when administered systemically; the brain is very sensitive to medications and can easily cause damage if a drug is administered directly into the bloodstream.
pH-triggered drug delivery systems are able to control the pharmacokinetics and the biodistribution of the drugs enclosed within the drug carrier and have a controlled release. Many “smart” pH-responsive drug delivery systems have not made it to clinical trials. [27] However, there still are many challenges with this treatment method. [10]
The conventional drug delivery system is the absorption of the drug across a biological membrane, whereas the targeted release system releases the drug in a dosage form. The advantages to the targeted release system is the reduction in the frequency of the dosages taken by the patient, having a more uniform effect of the drug, reduction of drug ...
Controlled drug release systems can be achieved through several methods. Rate-programmed drug delivery systems are tuned to the diffusivity of active agents across the membrane. [44] Another delivery-release mechanism is activation-modulated drug delivery, where the release is triggered by environmental stimuli.