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Because ZIF’s are porous, chemically stable, thermally stable, and tunable, they are potentially a platform for drug delivery and controlled drug release. ZIF-8 is very stable in water and aqueous sodium hydroxide solutions but decompose quickly in acidic solutions, indicating a pH sensitivity that could aid in the development of ZIF-based ...
In the medical field, reticular materials, particularly MOFs, are being assessed and tested for a variety of use-cases, from drug delivery systems to medical imaging. [ 35 ] [ 36 ] Their high surface area and biocompatibility allow them to be used as carriers for controlled release of therapeutic agents, offering targeted treatments with ...
An application of stretch-triggered drug delivery systems is the delivery of chemotherapy triggered by esophageal stent expansion. [4] Also, the incorporation of several drugs into stretch-triggered autonomous drug release systems is a possibility, allowing drugs to be released by the same or different signals. [ 1 ]
A computational study demonstrated that ZIF-4 and ZIF-8 materials undergo a shear softening mechanism with amorphizing (at ~ 0.34 GPa) of the material under hydrostatic loading, while still possessing a bulk modulus on the order of 6.5 GPa. [111] [112] Additionally, the ZIF-4 and ZIF-8 MOFs are subject to many pressure dependent phase transitions.
Drug delivery systems have been around for many years, but there are a few recent applications of drug delivery that warrant 1. Drug delivery to the brain: Many drugs can be harmful when administered systemically; the brain is very sensitive to medications and can easily cause damage if a drug is administered directly into the bloodstream.
ZIF-8 can be synthesized as a membrane on a porous alumina support and has proven to be effective at separating CO 2 from flue gas streams. At similar CO 2 /CH 4 selectivity to Y-type zeolite membranes, ZIF-8 membranes achieve unprecedented CO 2 permeance, two orders of magnitude above the previous standard. [24] Structure of a perovskite.
Conventional drug delivery is limited by the inability to control dosing, target specific sites, and achieve targeted permeability. Traditional methods of delivering therapeutics to the body experience challenges in achieving and maintaining maximum therapeutic effect while avoiding the effects of drug toxicity.
A Fe-N-C nanozyme was developed to study drug–drug interactions. [118] A polymeric nanozyme was developed for second near-infrared photothermal cancer ferrotherapy. [119] A Cu5.4O nanozyme was reported for anti-inflammation therapy. [120] A CeO 2 @ZIF-8 nanozyme was developed to treat reperfusion-induced injury in ischemic stroke. [121]
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