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Large-cell carcinoma (LCC), like small-cell carcinoma (SCC) is very rare and only accounts for about 5% of all cervical cancers. Early-stage LCC are extremely aggressive and difficult to diagnose due to the sub-mucosal location of the tumor and intact overlying mucosa. As with SCC, in LCC early cases are asymptomatic.
M8043/3 Small cell carcinoma, fusiform cell; M8044/3 Small cell carcinoma, intermediate cell; M8045/3 Combined small cell carcinoma Mixed small cell carcinoma; Combined small cell-large cell carcinoma; Combined small cell-adenocarcinoma; Combined small cell-squamous cell carcinoma; M8046/3 Non-small cell carcinoma (C34._)
Small-cell lung carcinoma (SCLC) has long been divided into two clinicopathological stages, termed limited stage (LS) and extensive stage (ES). [8] The stage is generally determined by the presence or absence of metastases, whether or not the tumor appears limited to the thorax, and whether or not the entire tumor burden within the chest can feasibly be encompassed within a single radiotherapy ...
In the late 1960s through 1971 a cluster of young women, from their teens into their twenties, was mysteriously diagnosed with clear-cell adenocarcinoma (CCA), a cancer not generally found in women until after menopause. Doctors at Massachusetts General Hospital eventually linked DES exposure before birth to the development of CCA in these ...
[8] [7] Cancer that has spread from the colon, bladder, and stomach is far more common than cancer that originates in the vagina itself. [9] Some benign tumors may later progress to become malignant tumors, such as vaginal cancers. [10] [11] Some neoplastic growths of the vagina are sufficiently rare as to be only described in case studies. [3]
Cervical adenocarcinoma is less likely to be caused by high-risk HPV strains than cervical squamous cell carcinoma is: around 10-15% of cervical adenocarcinomas are non-HPV-related. Cervical clear cell carcinoma (CCC) is typically HPV-negative, though many are p16 positive. [ 3 ]
Cytology of squamous metaplasia of the cervix, with typical features. Pap stain. Pap stain. Endometrial adenocarcinoma (carcinoma at left in image) with squamous differentiation evidenced as necrotic “ghost cells” of keratinocytes at right in image, leaving pink keratin as well as clear spaces at the prior locations of the cell nuclei.
The diagnosis is based on tissue examination, e.g. biopsy. [citation needed]Under the microscope, glassy cell carcinoma tumours are composed of cells with a glass-like cytoplasm, typically associated with an inflammatory infiltrate abundant in eosinophils and very mitotically active.