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For example, the risk of coronary heart disease was no higher among women aged 45 and over taking combined HRT, compared to those who had never taken it, according to a NICE adviser.
Dr. Manson’s research on the Women’s Health Initiative study suggests that hormone therapy does not reduce the risk for chronic diseases (think heart disease, stroke, cancer, and dementia ...
It may have a decreased risk of breast and colorectal cancer, though conversely it can be associated with vaginal bleeding, endometrial cancer, and increase the risk of stroke in women over age 60 years. [118] [119] Vaginal estrogen can improve local atrophy and dryness, with fewer systemic effects than estrogens delivered by other routes. [120]
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According to a cumulative 18-year follow-up analysis published in 2017, it was found that, among 27,347 postmenopausal women who had originally participated in the WHI hormone therapy trials, interventions using estrogen-plus-progestin and estrogen-alone were not associated with increased or decreased risk of all-cause, cardiovascular, or total ...
Hormone replacement therapy (HRT), also known as menopausal hormone therapy (MHT), is for women with menopausal symptoms. It is based on the idea that the treatment may prevent discomfort caused by diminished circulating estrogen and progesterone hormones, or in the case of the surgically or prematurely menopausal, that it may prolong life and may reduce incidence of dementia. [1]
However, there is up to a 30% increased risk of dementia for women starting estrogen-progestogen therapy after age 65 or more than 10 years after the final menstrual period.
So, the selective ERβ agitator has more clinical value for neurodegenerative diseases). In post-menopausal women, high levels of testosterone and estrogen higher the risk 2-3 times than lower level situation. Women that are not taking hormone replacement therapy (HRT) have lesser risk of breast cancer because of the insulin level increase. [18]
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