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In oncology, polycythemia vera (PV) is an uncommon myeloproliferative neoplasm in which the bone marrow makes too many red blood cells. [1] The majority of cases [ 2 ] are caused by mutations in the JAK2 gene, most commonly resulting in a single amino acid change in its protein product from valine to phenylalanine at position 617.
Papillomaviridae is a family of non-enveloped DNA viruses whose members are known as papillomaviruses. [1] Several hundred species of papillomaviruses, traditionally referred to as "types", [2] have been identified infecting all carefully inspected mammals, [2] but also other vertebrates such as birds, snakes, turtles and fish.
Parvalbumin (PV) is a calcium-binding protein with low molecular weight (typically 9-11 kDa). In humans, it is encoded by the PVALB gene. It is a member of the albumin family; it is named for its size ( parv- , from Latin parvus which means "small") and its ability to coagulate.
Granulomatosis with polyangiitis (GPA), formerly known as Wegener's granulomatosis (WG), [1] [2] [3] [4] [5] after German physician Friedrich Wegener, is a rare, long ...
In this particular case, it is a normal hereditary trait linked to a spotted coat color pattern and not a sign of disease. Mottle is a pattern of irregular marks, spots, streaks, blotches or patches of different shades or colours. It is commonly used to describe the surface of plants or the skin of animals.
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The cancer formulation of the drug, known as PV-10, is currently undergoing clinical trials for melanoma, [2] breast cancer. [ 3 ] and neuroendocrine tumors . The company also has formulated a drug based on rose bengal for the treatment of eczema and psoriasis ; this drug, PV-10, is currently in clinical trials as well.
Cyanosis is the change of body tissue color to a bluish-purple hue, as a result of decrease in the amount of oxygen bound to the hemoglobin in the red blood cells of the capillary bed. [1] Cyanosis is apparent usually in the body tissues covered with thin skin , including the mucous membranes , lips, nail beds , and ear lobes. [ 1 ]
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