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Scrapie (/ ˈ s k r eɪ p i /) is a fatal, degenerative disease affecting the nervous systems of sheep and goats. [1] It is one of several transmissible spongiform encephalopathies (TSEs), and as such it is thought to be caused by a prion. [2] [3] Scrapie has been known since at least 1732 and does not appear to be transmissible to humans.
5621 19122 Ensembl ENSG00000171867 ENSMUSG00000079037 UniProt P04156 P04925 RefSeq (mRNA) NM_183079 NM_000311 NM_001080121 NM_001080122 NM_001080123 NM_001271561 NM_001278256 NM_011170 RefSeq (protein) NP_000302 NP_001073590 NP_001073591 NP_001073592 NP_001258490 NP_898902 NP_000302.1 NP_001073590.1 NP_001073591.1 NP_001073592.1 NP_898902.1 NP_001265185 NP_035300 Location (UCSC) Chr 20: 4.69 ...
Scrapie: Sheep and goats: Scrapie prion PrP Sc: Yes 90.001.0.01.002. Transmissible mink encephalopathy (TME) Mink: TME prion PrP TME: No 90.001.0.01.003. Chronic wasting disease (CWD) Elk, white-tailed deer, mule deer and red deer: CWD prion PrP CWD: Yes 90.001.0.01.004. Bovine spongiform encephalopathy (BSE) commonly known as "mad cow disease ...
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National Security Agency: Military national defense: 1.9 trillion call-detail records (estimated) Assessed internally as "51% confidence" of being foreign: Consumer transactions [6] [7] Consumer Financial Protection Bureau: at least 10 million consumers: data at least partially anonymized: Usual residency: Census: Census: assignment of federal ...
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In his 1998 PNAS review article on Prions, Prusiner wrote: [10] "The idea that scrapie prions were composed of an amyloidogenic protein was truly heretical when it was introduced" (by Tikvah Alper [11] [12]). Encephalopathy was a mysterious disease that attacks the brain, and leaves the brains of its victims full of holes.
BSE is a degenerative infection of the central nervous system in cattle. It is a fatal disease, similar to scrapie in sheep and goats, caused by a prion.A major epizootic affected the UK, and to a lesser extent a number of other countries, between 1986 and the 2000s, infecting more than 190,000 animals, not counting those that remained undiagnosed.