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The notion of doubling time dates to interest on loans in Babylonian mathematics. Clay tablets from circa 2000 BCE include the exercise "Given an interest rate of 1/60 per month (no compounding), come the doubling time." This yields an annual interest rate of 12/60 = 20%, and hence a doubling time of 100% growth/20% growth per year = 5 years.
The formula above can be used for more than calculating the doubling time. If one wants to know the tripling time, for example, replace the constant 2 in the numerator with 3. As another example, if one wants to know the number of periods it takes for the initial value to rise by 50%, replace the constant 2 with 1.5.
The doubling time (t d) of a population is the time required for the population to grow to twice its size. [24] We can calculate the doubling time of a geometric population using the equation: N t = λ t N 0 by exploiting our knowledge of the fact that the population (N) is twice its size (2N) after the doubling time. [20]
The Gompertz curve or Gompertz function is a type of mathematical model for a time series, named after Benjamin Gompertz (1779–1865). It is a sigmoid function which describes growth as being slowest at the start and end of a given time period.
RGR is a concept relevant in cases where the increase in a state variable over time is proportional to the value of that state variable at the beginning of a time period. In terms of differential equations , if S {\displaystyle S} is the current size, and d S d t {\displaystyle {\frac {dS}{dt}}} its growth rate, then relative growth rate is
r = the population growth rate, which Ronald Fisher called the Malthusian parameter of population growth in The Genetical Theory of Natural Selection, [2] and Alfred J. Lotka called the intrinsic rate of increase, [3] [4] t = time. The model can also be written in the form of a differential equation: =
Small-cell lung carcinoma (SCLC) has long been divided into two clinicopathological stages, termed limited stage (LS) and extensive stage (ES). [8] The stage is generally determined by the presence or absence of metastases, whether or not the tumor appears limited to the thorax, and whether or not the entire tumor burden within the chest can feasibly be encompassed within a single radiotherapy ...
Therefore, the doubling time t d becomes a function of dilution rate D in steady state: t d = ln 2 D {\displaystyle t_{d}={\frac {\ln 2}{D}}} Each microorganism growing on a particular substrate has a maximal specific growth rate μ max (the rate of growth observed if growth is limited by internal constraints rather than external nutrients).