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Gout is a common form of inflammatory arthritis. It happens due to high levels of uric acid in the body. Researchers estimate that gout impacts one to four percent of people around the world.
Mutations in the gene lead to hyperuricemia.At least 67 disease-causing mutations in this gene have been discovered: [5] Some men have partial (up to 20% less activity of the enzyme) HGPRT deficiency that causes high levels of uric acid in the blood, which leads to the development of gouty arthritis and the formation of uric acid stones in the urinary tract.
A 2011 survey in the United States indicated that 3.9% of the population had gout, whereas 21.4% had hyperuricemia without having symptoms. [ 43 ] Excess blood uric acid (serum urate) can induce gout , [ 44 ] a painful condition resulting from needle-like crystals of uric acid termed monosodium urate crystals [ 45 ] precipitating in joints ...
Gout presenting as slight redness in the metatarsophalangeal joint of the big toe. Gout can present in several ways, although the most common is a recurrent attack of acute inflammatory arthritis (a red, tender, hot, swollen joint). [4] The metatarsophalangeal joint at the base of the big toe is affected most often, accounting for half of cases ...
Symptoms can include gout, anaemia, epilepsy, delayed development, deafness, compulsive self-biting, kidney failure or stones, or loss of immunity. Purine metabolism can have imbalances that can arise from harmful nucleotide triphosphates incorporating into DNA and RNA which further lead to genetic disturbances and mutations, and as a result ...
“Gout is a common type of arthritis that can be extremely painful,” Dr. Tochi Iroku-Malize, board chair of the American Academy of Family Physicians, tells Yahoo Life. “Symptoms include ...
Gouty arthritis can become particularly painful and potentially debilitating when gout cannot successfully be treated. [81] When uric acid levels and gout symptoms cannot be controlled with standard gout medicines that decrease the production of uric acid (e.g., allopurinol) or increase uric acid elimination from the body through the kidneys (e ...
20521 Ensembl ENSG00000197891 ENSMUSG00000061742 UniProt Q96S37 Q8CFZ5 RefSeq (mRNA) NM_001276326 NM_001276327 NM_144585 NM_153378 NM_009203 RefSeq (protein) NP_001263255 NP_001263256 NP_653186 NP_700357 NP_033229 Location (UCSC) Chr 11: 64.59 – 64.6 Mb Chr 19: 6.59 – 6.59 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Solute carrier family 22 (organic anion/cation transporter ...
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