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Ergotism (pron. / ˈ ɜːr ɡ ə t ˌ ɪ z ə m / UR-gət-iz-əm) is the effect of long-term ergot poisoning, traditionally due to the ingestion of the alkaloids produced by the Claviceps purpurea fungus—from the Latin clava "club" or clavus "nail" and -ceps for "head", i.e. the purple club-headed fungus—that infects rye and other cereals, and more recently by the action of a number of ...
He also states that the adrenergic blockage by ergopeptines (e.g., ergovaline or ergotamine) leads to potent and long-term vasoconstriction, and can result in reduced blood flow resulting in intense burning pain (St. Anthony's fire), edema, cyanosis, dry gangrene and even loss of hooves in cattle or limbs in humans.
St. Anthony's fire (also known historically as Ignis Sacer and Holy Fire) may refer to: Ergotism, the effect of long-term ergot poisoning, traditionally due to the ingestion of alkaloids; Erysipelas, an acute infection, typically with a skin rash; St Anthony's Fire, a 1994 Doctor Who novel by Mark Gatiss
Ergoline alkaloids were first isolated from ergot, a fungus that infects rye and causes ergotism or St. Anthony's fire. [21] Reports of the toxic effects due to ergoline alkaloids date back to the 12th century. [22] Ergot also has a long history of medicinal use, which led to attempts to characterize its activity chemically.
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An overdose produces a characteristic poisoning, ergotism or "St. Anthony's fire": prolonged vasospasm resulting in gangrene and amputations; hallucinations and dementia; and abortions. Gastrointestinal disturbances such as diarrhea, nausea, and vomiting, are common. [15] The drug is contraindicated in pregnancy, vascular disease, and psychosis.
The work contains a number of references to Saint Anthony and Saint Anthony's fire. The congregation was founded c. 1095 by Gaston of Valloire, a nobleman of the Dauphiné, and his son, and confirmed by Pope Urban II in the same year, in thanksgiving for the son's miraculous cure from Saint Anthony's fire thanks to the relics of Saint Anthony ...
Ergotamine interacts with serotonin, adrenergic, and dopamine receptors. [17] [18] It is an agonist of serotonin receptors including the 5-HT 1 and 5-HT 2 subtypes. [17]Ergotamine is an agonist of the serotonin 5-HT 2B receptor and has been associated with cardiac valvulopathy. [19]