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Acetophenone is formed as a byproduct of the cumene process, the industrial route for the synthesis of phenol and acetone.In the Hock rearrangement of isopropylbenzene hydroperoxide, migration of a methyl group rather than the phenyl group gives acetophenone and methanol as a result of an alternate rearrangement of the intermediate:
First stage of Hock process: alkylation of benzene with propylene. Second stage of Hock process: autoxidation of cumene. The cumene process (cumene-phenol process, Hock process) is an industrial process for synthesizing phenol and acetone from benzene and propylene.
Phenacyl chloride, also commonly known as chloroacetophenone, is a substituted acetophenone.It is a useful building block in organic chemistry.Apart from that, it has been historically used as a riot control agent, where it is designated CN. [5]
An example of this reaction is the synthesis of 1-phenylethylamine from acetophenone: [14] Reductive amination acetophenone ammonia. Additionally, many systems catalyze reductive aminations with hydrogenation catalysts. [15]
Organic synthesis is an important chemical process that is integral to many scientific fields. Examples of fields beyond chemistry that require organic synthesis include the medical industry, pharmaceutical industry, and many more. Organic processes allow for the industrial-scale creation of pharmaceutical products.
The initial product is a thioamide for example that of acetophenone [7] which can again be hydrolyzed to the amide. The reaction is named after Karl Kindler The Kindler modification of the Willgerodt rearrangement. A possible reaction mechanism for the Kindler variation is depicted below: [8]
The Bischler–Möhlau indole synthesis, also often referred to as the Bischler indole synthesis, [1] is a chemical reaction that forms a 2-aryl-indole from an α-bromo-acetophenone and excess aniline; it is named after August Bischler and Richard Möhlau .
Chalcone is usually prepared by an aldol condensation between benzaldehyde and acetophenone. [ 6 ] This reaction, which can be carried out without any solvent, is so reliable that it is often given as an example of green chemistry in undergraduate education.