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The TTSI is used as a screening parameter for resistance to thyroid hormone due to mutations in the THRB gene, where it is elevated. [4] It is also beneficial for assessing the severity of already confirmed thyroid hormone resistance, [ 6 ] even on replacement therapy with L-T4, [ 7 ] and for monitoring the pituitary response to substitution ...
Thyroid function tests (TFTs) is a collective term for blood tests used to check the function of the thyroid. [1] TFTs may be requested if a patient is thought to suffer from hyperthyroidism (overactive thyroid) or hypothyroidism (underactive thyroid), or to monitor the effectiveness of either thyroid-suppression or hormone replacement therapy.
Thyroid's secretory capacity (G T, also referred to as thyroid's incretory capacity, maximum thyroid hormone output, T4 output or, if calculated from serum levels of thyrotropin and thyroxine, as SPINA-GT [a]) is the maximum stimulated amount of thyroxine that the thyroid can produce in a given time-unit (e.g. one second).
Free T4 and total T3 can be measured when hyperthyroidism is of high suspicion as it will improve the accuracy of the diagnosis. Free T4, total T3 or both are elevated and serum TSH is below normal in hyperthyroidism. If the hyperthyroidism is mild, only serum T3 may be elevated and serum TSH can be low or may not be detected in the blood. [14]
In sub-clinical hyperthyroidism, serum TSH is abnormally low, but T4- and T3-levels fall within laboratory reference ranges. [47] It primarily affects the skeleton and the cardiovascular system (abnormalities in other systems have also been reported), in a similar but less severe and less frequent way than overt hyperthyroidism does.
Jostel's TSH index (TSHI or JTI), also referred to as Jostel's thyrotropin index or Thyroid Function index (TFI), is a method for estimating the thyrotropic (i.e. thyroid stimulating) function of the anterior pituitary lobe in a quantitative way.
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TSH is the preferred initial test of thyroid function as it has a higher sensitivity to changes in thyroid status than free T 4. [ 60 ] Time of day can affect the results of this test; TSH peaks early in the morning and slumps in the late afternoon to early evening, [ 61 ] with "a variation in TSH by a mean of between 0.95 m IU /mL to 2.0 mIU ...
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