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  2. TANK-binding kinase 1 - Wikipedia

    en.wikipedia.org/wiki/TANK-binding_kinase_1

    TBK1 (TANK-binding kinase 1) is an enzyme with kinase activity. Specifically, it is a serine / threonine protein kinase. [5] It is encoded by the TBK1 gene in humans. [6] This kinase is mainly known for its role in innate immunity antiviral response. However, TBK1 also regulates cell proliferation, apoptosis, autophagy, and anti-tumor immunity. [5]

  3. Stimulator of interferon genes - Wikipedia

    en.wikipedia.org/wiki/Stimulator_of_interferon_genes

    Upon activation, STING stimulates TBK1 activity to phosphorylate IRF3 or STAT6. Phosphorylated IRF3s and STAT6s dimerize, and then enter nucleus to stimulate expression of genes involved in host immune response, such as IFNB, CCL2, CCL20, etc. [8] [23] Several reports suggested that STING is associated with the activation of selective autophagy ...

  4. TBK1 - Wikipedia

    en.wikipedia.org/wiki/TBK1

    TBK1 may refer to: TANK-binding kinase 1, an enzyme; IkappaB kinase, an enzyme This page was last edited on 30 December 2019, at 15:16 (UTC). Text is available under ...

  5. Genetics of amyotrophic lateral sclerosis - Wikipedia

    en.wikipedia.org/wiki/Genetics_of_amyotrophic...

    The TBK1, [36] SQSTM1, [37] and OPTN [38] genes are involved in producing a maturing autophagosome during autophagy. In 2016, it was observed that mutations in the TBK1 protein contributed to formation of the disease. [39] Since the TBK1 protein is haploinsufficient, meaning mutations in the gene result in no protein production. [36]

  6. IKBKE - Wikipedia

    en.wikipedia.org/wiki/IKBKE

    56489 Ensembl ENSG00000263528 ENSMUSG00000042349 UniProt Q14164 Q9R0T8 RefSeq (mRNA) NM_001193321 NM_001193322 NM_014002 NM_019777 RefSeq (protein) NP_001180250 NP_001180251 NP_054721 NP_062751 Location (UCSC) Chr 1: 206.47 – 206.5 Mb Chr 1: 131.18 – 131.21 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Inhibitor of nuclear factor kappa-B kinase subunit epsilon also known as I ...

  7. cGAS–STING cytosolic DNA sensing pathway - Wikipedia

    en.wikipedia.org/wiki/CGAS–STING_cytosolic_DNA...

    The cGAS–STING pathway is a component of the innate immune system that functions to detect the presence of cytosolic DNA and, in response, trigger expression of inflammatory genes that can lead to senescence [1] or to the activation of defense mechanisms.

  8. IκB kinase - Wikipedia

    en.wikipedia.org/wiki/IκB_kinase

    Inhibition of IκB kinase (IKK) and IKK-related kinases, IKBKE (IKKε) and TANK-binding kinase 1 (TBK1), has been investigated as a therapeutic option for the treatment of inflammatory diseases and cancer. [11] The small-molecule inhibitor of IKK-β SAR113945, developed by Sanofi-Aventis, was evaluated in patients with knee osteoarthritis. [11 ...

  9. MAP3K8 - Wikipedia

    en.wikipedia.org/wiki/MAP3K8

    1326 26410 Ensembl ENSG00000107968 ENSMUSG00000024235 UniProt P41279 Q07174 RefSeq (mRNA) NM_001244134 NM_005204 NM_001320961 NM_007746 RefSeq (protein) NP_001231063 NP_001307890 NP_005195 NP_031772 Location (UCSC) Chr 10: 30.43 – 30.46 Mb Chr 18: 4.33 – 4.35 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Mitogen-activated protein kinase kinase kinase 8 is an enzyme that in ...