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The first function described for TLR4 was the recognition of exogenous molecules from pathogens (PAMPs), in particular LPS molecules from gram-negative bacteria. [13] As pattern recognition receptor, TLR4 plays a fundamental role in pathogen recognition and activation of innate immunity which is the first line of defense against invading micro-organisms.
TLR4 is the only TLR that uses all four adaptors. Complex consisting of TLR4, MD2 and LPS recruits TIR domain-containing adaptors TIRAP and MyD88 and thus initiates activation of NFκB (early phase) and MAPK. TLR4-MD2-LPS complex then undergoes endocytosis and in endosome it forms a signaling complex with TRAM and TRIF adaptors.
56480 Ensembl ENSG00000183735 ENSMUSG00000020115 UniProt Q9UHD2 Q9WUN2 RefSeq (mRNA) NM_013254 NM_019786 RefSeq (protein) NP_037386 NP_062760 Location (UCSC) Chr 12: 64.45 – 64.5 Mb Chr 10: 121.38 – 121.42 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse TBK1 (TANK-binding kinase 1) is an enzyme with kinase activity. Specifically, it is a serine / threonine protein kinase. It is ...
TLRs tend to dimerize, TLR4 forms homodimers, and TLR6 can dimerize with either TLR1 or TLR2. [10] Interaction of TLRs with their specific PAMP is mediated through either MyD88 -dependent pathway and triggers the signaling through NF-κB and the MAP kinase pathway and therefore the secretion of pro-inflammatory cytokines and co-stimulatory ...
TBK1 may refer to: TANK-binding kinase 1, an enzyme; IkappaB kinase, an enzyme This page was last edited on 30 December 2019, at 15:16 (UTC). Text is available under ...
TLR4-agonistic DAMPs also induce renal dendritic cells to release IL-22, which also accelerates tubule re-epithelialization in acute kidney injury. Finally, DAMPs also promote renal fibrosis by inducing NLRP3, which also promotes TGF-β receptor signaling.
7096 21897 Ensembl ENSG00000174125 ENSMUSG00000044827 UniProt Q15399 Q9EPQ1 RefSeq (mRNA) NM_003263 NM_001276445 NM_030682 RefSeq (protein) NP_003254 NP_001263374 NP_109607 Location (UCSC) Chr 4: 38.79 – 38.86 Mb Chr 5: 65.08 – 65.09 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Toll-like receptor 1 (TLR1) is a member of the toll-like receptor (TLR) family of pattern ...
56489 Ensembl ENSG00000263528 ENSMUSG00000042349 UniProt Q14164 Q9R0T8 RefSeq (mRNA) NM_001193321 NM_001193322 NM_014002 NM_019777 RefSeq (protein) NP_001180250 NP_001180251 NP_054721 NP_062751 Location (UCSC) Chr 1: 206.47 – 206.5 Mb Chr 1: 131.18 – 131.21 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Inhibitor of nuclear factor kappa-B kinase subunit epsilon also known as I ...