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Chelation (/ k iː ˈ l eɪ ʃ ən /) is a type of bonding of ions and their molecules to metal ions. It involves the formation or presence of two or more separate coordinate bonds between a polydentate (multiple bonded) ligand and a single central metal atom.
Anal Bioanal Chem Analytical and Bioanalytical Chemistry 381.6 (2005): 1103-113. R. R. Greenberg" and H. M. Kingston. “Trace Element Analysis of Natural Water Samples by Neutron Activation Analysis with Chelating Resin.” Center for Analytical Chemistry, National Bureau of Standards, Washington, D.C. 20234.
DOTA is derived from the macrocycle known as cyclen.The four secondary amine groups are modified by replacement of the N-H centers with N-CH 2 CO 2 H groups. The resulting aminopolycarboxylic acid, upon ionization of the carboxylic acid groups, is a high affinity chelating agent for di- and trivalent cations.
In coordination chemistry, the bite angle is the angle on a central atom between two bonds to a bidentate ligand. This ligand–metal–ligand geometric parameter is used to classify chelating ligands, including those in organometallic complexes.
Metal–EDTA chelate as found in Co(III) complexes Structure of [Fe(EDTA)(H 2 O)] −, showing that the EDTA 4− ligand does not fully encapsulate Fe(III), which is seven-coordinate [27] In coordination chemistry, EDTA 4− is a member of the aminopolycarboxylic acid family of ligands.
This enhanced stability, called the chelate effect, is usually attributed to effects of entropy, which favors the displacement of many ligands by one polydentate ligand. Related to the chelate effect is the macrocyclic effect. A macrocyclic ligand is any large ligand that at least partially surrounds the central atom and bonds to it, leaving ...
Chelators can be used in chelation therapy to remove toxic metals in the body. TPEN is a chelator that has a high affinity for zinc. TPEN is a chelator that has a high affinity for zinc. For example, one study showed that TPEN is a stronger chelator compared to other chelators like pentetic acid (DTPA) when high levels of zinc are present (15 μM).
Chelation therapy is a medical procedure that involves the administration of chelating agents to remove heavy metals from the body. [1] Chelation therapy has a long history of use in clinical toxicology [2] and remains in use for some very specific medical treatments, although it is administered under very careful medical supervision due to various inherent risks, including the mobilization of ...