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At the enterocyte cell wall, β-carotene is taken up by the membrane transporter protein scavenger receptor class B, type 1 (SCARB1). Absorbed β-carotene is then either incorporated as such into chylomicrons or first converted to retinal and then retinol, bound to retinol binding protein 2, before being incorporated into chylomicrons. [8]
Also downregulated is the enzyme beta-carotene 15,15'-dioxygenase (formerly known as beta-carotene 15,15'-monooxygenase) coded for by the BCMO1 gene, responsible for symmetrically cleaving β-carotene into retinal. [8] Absorbed β-carotene is either incorporated as such into chylomicrons or first converted to retinal and then retinol, bound to ...
Beta-carotene 15,15'-monooxygenase (BCO1; EC 1.14.99.36) from animals, which cleaves beta-carotene symmetrically at the central double bond to yield two molecules of retinal. [ 3 ] Beta-carotene-9',10'-dioxygenase (BCO2) from animals, which cleaves beta-carotene asymmetrically to apo-10'-beta-carotenal and beta-ionone, the latter being ...
63857 Ensembl ENSG00000135697 ENSMUSG00000031845 UniProt Q9HAY6 Q9JJS6 RefSeq (mRNA) NM_017429 NM_001163028 NM_021486 RefSeq (protein) NP_059125 NP_001156500 NP_067461 Location (UCSC) Chr 16: 81.24 – 81.29 Mb Chr 8: 117.82 – 117.86 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse In enzymology, beta-carotene 15,15'-dioxygenase, (EC 1.13.11.63) is an enzyme with systematic name ...
catalyzed by a beta-carotene 15,15'-monooxygenase [8] or a beta-carotene 15,15'-dioxygenase. [ 9 ] Just as carotenoids are the precursors of retinal, retinal is the precursor of the other forms of vitamin A. Retinal is interconvertible with retinol , the transport and storage form of vitamin A:
Carotenoid-9',10'-cleaving dioxygenase (EC 1.13.11.71, BCO2 (gene), beta-carotene 9',10'-monooxygenase (misleading)) is an enzyme with systematic name all-trans-beta ...
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