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Schizophrenia is a primary psychotic disorder, whereas, bipolar disorder is a primary mood disorder which can also involve psychosis. Both schizophrenia and bipolar disorder are characterized as critical psychiatric disorders in the Diagnostic and Statistical Manual of Mental Disorders fifth edition (DSM-5). [1]
Schizophrenia is a mental disorder [17] [7] characterized variously by hallucinations (typically, hearing voices), delusions, disorganized thinking and behavior, [10] and flat or inappropriate affect. [7] Symptoms develop gradually and typically begin during young adulthood and are never resolved.
Since Emil Kraepelin's distinction between bipolar disorder and schizophrenia in the 19th century, researchers have defined a spectrum of different types of bipolar disorder. Bipolar spectrum disorders include: bipolar I disorder, bipolar II disorder, cyclothymic disorder and cases where subthreshold symptoms are found to cause clinically ...
Specific symptoms have been linked to various neuroimaging abnormalities in bipolar disorder, as well as schizophrenia. Reality distortion, disorganization, and psychomotor poverty have been linked to prefrontal, thalamic, and striatal regions in both schizophrenia and bipolar (Table 1). [79]
Bipolar disorder is often a lifelong condition, and patients should be followed up regularly for relapse prevention. [27] Although BP-II is thought to be less severe than BP-I in regard to symptom intensity, BP-II is associated with higher frequencies of rapid cycling and depressive episodes. [ 28 ]
Schizoaffective disorder is a mental disorder characterized by symptoms of both schizophrenia and a mood disorder, either bipolar disorder or depression. [4] [5] The main diagnostic criterion is the presence of psychotic symptoms for at least two weeks without prominent mood symptoms. [5]
Bipolar I disorder (BD-I; pronounced "type one bipolar disorder") is a type of bipolar spectrum disorder characterized by the occurrence of at least one manic episode, with or without mixed or psychotic features. [1] Most people also, at other times, have one or more depressive episodes. [2]
Emil Kraepelin (1856–1926). The Kraepelinian dichotomy is the division of the major endogenous psychoses into the disease concepts of dementia praecox, which was reformulated as schizophrenia by Eugen Bleuler by 1908, [1] [2] and manic-depressive psychosis, which has now been reconceived as bipolar disorder. [3]
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