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Whereas the IC 50 value for a compound may vary between experiments depending on experimental conditions, (e.g. substrate and enzyme concentrations) the K i is an absolute value. K i is the inhibition constant for a drug; the concentration of competing ligand in a competition assay which would occupy 50% of the receptors if no ligand were present.
For competition binding assays and functional antagonist assays IC 50 is the most common summary measure of the dose-response curve. For agonist/stimulator assays the most common summary measure is the EC 50. [6] The EC 50 is also related to IC 50 which is a measure of a compound's inhibition (50% inhibition).
Although cost indexes do not usually forecast future escalation, the IC Index stands out for presenting a smaller delay between release date and index date, besides a 12 months forecast. [8] On the other hand, the index is only available from January 2000 (with a value of 100). A sample is available at Intratec’s website. [9]
Ligand efficiency is a measurement of the binding energy per atom of a ligand to its binding partner, such as a receptor or enzyme. [1]Ligand efficiency is used in drug discovery research programs to assist in narrowing focus to lead compounds with optimal combinations of physicochemical properties and pharmacological properties.
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Toxic units (TU) are used in the field of toxicology to quantify the interactions of toxicants in binary mixtures of chemicals. [1] A toxic unit for a given compound is based on the concentration at which there is a 50% effect (ex. EC50) for a certain biological endpoint.
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For oral drugs, a LogP value comprised between 2 and 3 is often considered optimal to achieve a compromise between permeability and first-pass clearance. LiPE allows capturing both values in a single parameter, and empirical evidence suggest that quality drug candidates have a high LiPE (>6); this value corresponds to a compound with a pIC 50 ...