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The fissure may be increased in vertical height in Graves' disease, which is manifested as Dalrymple's sign. It is seen in disorders such as cri-du-chat syndrome. In animal studies using four times the therapeutic concentration of the ophthalmic solution latanoprost, the size of the palpebral fissure can be increased. The condition is reversible.
Blepharophimosis is a congenital anomaly in which the eyelids are underdeveloped such that they cannot open as far as usual and permanently cover part of the eyes. Both the vertical and horizontal palpebral fissures (eyelid openings) are shortened; the eyes also appear spaced more widely apart as a result, known as telecanthus.
Upslanting palpebral fissures; Skeletal indicators Tapering fingers; Hypotonia; Genetics. This condition is caused by mutations in the NR2F1 gene.
2. Angle B, Holgado S, Burton BK (1994) Microcephaly, lymphoedema, and chorioretinal dysplasia: report of two additional cases. Am J Med Genet; 53:99-101; 3. Fryns JP, Smeets E, Van den Berghe H. (1995) On the nosology of the "primary true microcephaly, chorioretinal dysplasia, lymphoedema" association. Clin Genet; 48:131-133
In biological morphology and anatomy, a sulcus (pl.: sulci) is a furrow or fissure (Latin fissura, pl.: fissurae). It may be a groove, natural division, deep furrow, elongated cleft, or tear in the surface of a limb or an organ, most notably on the surface of the brain , but also in the lungs , certain muscles (including the heart ), as well as ...
Wiedemann–Steiner syndrome (WSS) [2] is a rare genetic disorder that causes developmental delay, unusual facial features, short stature, and reduction in muscle tone . The syndrome was originally described in 1989 [3] by Hans-Rudolf Wiedemann. The genetic basis for the syndrome was identified by Dr. Wendy D. Jones in 2012. [4]
In mild disease, patients present with eyelid retraction. In fact, upper eyelid retraction is the most common ocular sign of Graves' orbitopathy. This finding is associated with lid lag on infraduction (Von Graefe's sign), eye globe lag on supraduction (Kocher's sign), a widened palpebral fissure during fixation (Dalrymple's sign) and an incapacity of closing the eyelids completely ...
Small palpebral fissures: Eye width decreases with increased prenatal alcohol exposure. Measurement of FAS facial features uses criteria developed by the University of Washington . The lip and philtrum are measured by a trained physician with the Lip-Philtrum Guide, [ 85 ] a five-point Likert scale with representative photographs of lip and ...