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The neurotransmitter serotonin (illustration) has various receptors. A serotonin receptor agonist is an agonist of one or more serotonin receptors. They activate serotonin receptors in a manner similar to that of serotonin (5-hydroxytryptamine; 5-HT), a neurotransmitter and hormone and the endogenous ligand of the serotonin receptors.
5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. [1][2][3] They mediate both excitatory and inhibitory neurotransmission. The serotonin (i.e., 5-hydroxytryptamine, hence "5-HT") receptors are ...
Infobox references. Serotonin (/ ˌsɛrəˈtoʊnɪn, ˌsɪərə -/) [6][7][8] or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter. Its biological function is complex, touching on diverse functions including mood, cognition, reward, learning, memory, and numerous physiological processes such as vomiting and vasoconstriction.
[39] [40] It is also known to bind with high affinity to other serotonin receptors, including the serotonin 5-HT 1A, 5-HT 1B, 5-HT 1D, and 5-HT 3 receptors, and is likely to be a serotonin 5-HT 4 receptor agonist. [2] [40] In addition to its serotonin receptor agonism, bufotenin is a potent serotonin releasing agent with an EC 50 Tooltip half ...
Fenfluramine acts as a serotonin and norepinephrine releasing agent, agonist of the serotonin 5-HT 2 receptors, and sigma σ 1 receptor positive modulator. [12] [13] [14] Its mechanism of action in the treatment of seizures is unknown, [3] but may involve increased activation of certain serotonin receptors and the sigma σ 1 receptor.
15557 Ensembl ENSG00000179097 ENSMUSG00000050783 UniProt P30939 Q02284 RefSeq (mRNA) NM_000866 NM_001322208 NM_001322209 NM_001322210 NM_008310 RefSeq (protein) NP_000857 NP_001309137 NP_001309138 NP_001309139 NP_032336 Location (UCSC) Chr 3: 87.79 – 87.99 Mb Chr 16: 64.75 – 64.93 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse 5-hydroxytryptamine (serotonin) receptor 1F, also ...
Lasmiditan is a serotonin receptor agonist that, like the unsuccessful LY-334,370, selectively binds to the 5-HT 1F receptor subtype. A number of triptans have been shown to act on this subtype as well, but only after their affinity for 5-HT 1B and 5-HT 1D has been made responsible for their anti-migraine activity.
Naratriptan. Naratriptan (trade names include Amerge) is a triptan drug marketed by GlaxoSmithKline and is used for the treatment of migraine headaches. It is a selective 5-HT 1 receptor subtype agonist. It was patented in 1987 and approved for medical use in 1997. [1]