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Idecabtagene vicleucel, sold under the brand name Abecma, is a cell-based gene therapy to treat multiple myeloma. [3] [7] [8]The most common side effects include cytokine release syndrome (CRS), infections, fatigue, musculoskeletal pain, and a weakened immune system (hypogammaglobulinemia).
[133] [134] Manufacturers of CAR T cells have developed alternative payment programs due to the high cost of CAR T therapy, such as by requiring payment only if the CAR T therapy induces a complete remission by a certain time point after treatment. [135] Additionally, CAR T cell therapies are not available worldwide yet. CAR T cell therapies ...
Moreover, CAR-T treatment seems to provide a deeper, ... A 2016 study concluded that stem cell transplant is the preferred treatment for multiple myeloma. [107]
The black box warning that the agency has asked the companies to include states, “T-cell malignancies may occur following treatment with BCMA- and CD19-directed genetically modified autologous T ...
Maksim Mamonkin, a CAR-T expert at Baylor College of Medicine's Center for Cell and Gene Therapy, who oversees production of CAR-T treatments, said in clinical trials, secondary cancers are ...
The major application of CAR-T immunotherapy is to treat hematological malignancies, such as multiple myeloma, chronic lymphocytic leukemia, acute lymphoblastic leukemia and lymphoma. [8] Also, CAR-T-related solid tumor treatments have become increasingly promising due to protein and cell engineering improvements. [9]
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