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Ovarian tumours by incidence and risk of ovarian cancer, with adult granulosa cell tumour at right [7] Using next generation DNA sequencing, 97% of adult granulosa cell tumours were found to contain an identical mutation in the FOXL2 gene . This is a somatic mutation, meaning it is not usually transmitted to descendants.
A granulosa cell or follicular cell is a somatic cell of the sex cord that is closely associated with the developing female gamete (called an oocyte or egg) in the ovary of mammals. Structure and function
Sex cord-stromal tumor, including estrogen-producing granulosa cell tumor, the benign thecoma, and virilizing Sertoli-Leydig cell tumor or arrhenoblastoma, accounts for 7% of ovarian cancers. They occur most frequently in women between 50 and 69 years of age but can occur in women of any age, including young girls.
Sex cord–gonadal stromal tumour is a group of tumours derived from the stromal component of the ovary and testis, which comprises the granulosa, thecal cells and fibrocytes. [1] In contrast, the epithelial cells originate from the outer epithelial lining surrounding the gonad while the germ cell tumors arise from the precursor cells of the ...
The granulosa cells are usually arranged haphazardly around the space. They are pathognomonic for granulosa cell tumors. Histologically, these tumors consists of monotonous islands of granulosa cells with "coffee-bean" nuclei. That same nuclear groove appearance noted in Brenner tumour, an epithelial-stromal ovarian tumor distinguishable by ...
Granulosa cell tumors, while rare (less than 5% of ovarian cancers), may both granulosa cells and theca cells. [6] Thecomas are benign proliferations of theca cells that may present with hormonal dysfunction. [7] Theca cells (along with granulosa cells) form the corpus luteum during oocyte maturation.
Ovarian tumors, or ovarian neoplasms, are tumors in the ovary. [1] Not all are ovarian cancer. [1] They consist of mainly solid tissue, while ovarian cysts contain fluid. [2]In 2020, the World Health Organization (WHO) divided ovarian tumours as 90% epithelial, 3% germ cell, and 2% sex cord-stromal types.
Transitional cell carcinoma is an even rarer entity, in which neoplastic transitional epithelial cells similar to transitional cell carcinoma of the bladder are seen in the ovary, without the characteristic stromal/epithelial pattern of a Brenner tumour. Histologically, Leydig cell tumours of the testes and ovarian stromal Leydig cell tumours ...