Search results
Results from the WOW.Com Content Network
Celecoxib, sold under the brand name Celebrex among others, is a COX-2 inhibitor and nonsteroidal anti-inflammatory drug (NSAID). [7] It is used to treat the pain and inflammation in osteoarthritis , acute pain in adults, rheumatoid arthritis , psoriatic arthritis , ankylosing spondylitis , painful menstruation , and juvenile rheumatoid ...
The SO 2 CH 3 can be replaced by SO 2 NH 2, wherein the lipophilic pocket is occupied by an optionally substituted phenyl ring or a bulky alkoxy substituent (celecoxib). Within the hydrophilic side-pocket of COX-2, the oxygen of the sulfonamide (or sulfone ) group interacts with Hist90, Arg513, and Gln 192 and forms hydrogen bonds .
In the CLASS trial which compared Celebrex 800 mg/day to ibuprofen 2400 mg/day and diclofenac 150 mg/day for osteoarthritis or rheumatoid arthritis for six months, Celebrex was associated with significantly fewer upper gastrointestinal complications (0.44% vs. 1.27%, p = 0.04), with no significant difference in incidence of cardiovascular ...
The 7-year-old canine with a love for fast food weighed a whopping 38 pounds (17.24 kg) with a body mass index of over 60 percent body fat in September. Morbidly plump Texas wiener dog loses ...
When you bring a new dog into your home, it may take a few weeks before he trusts he is part of the family. The more confident the dog, the sooner he will enjoy getting a belly rub. Dog having ...
Researchers examined 20 YouTube videos showing dogs playing together and 'staged' play sessions with a medium-sized female dog paired with 33 dogs of different breeds and sizes. Then, they sat ...
Clinical signs include depression, loss of appetite, vomiting blood, weakness, and shock. Treatment is as above for recent exposure. When hypercalcemia occurs (which can take 1 to 2 weeks), treatment is with intravenous fluids (saline), diuretics, corticosteroids, and calcitonin. Long term prognosis is good once the dog is stabilized.
Orlistat (Xenical), the most commonly used medication to treat obesity and sibutramine (Meridia), a medication that was withdrawn due to cardiovascular side effects. Anti-obesity medication or weight loss medications are pharmacological agents that reduce or control excess body fat.