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The development of the nervous system in humans, or neural development, or neurodevelopment involves the studies of embryology, developmental biology, and neuroscience.These describe the cellular and molecular mechanisms by which the complex nervous system forms in humans, develops during prenatal development, and continues to develop postnatally.
The process begins when the notochord induces the formation of the central nervous system (CNS) by signaling the ectoderm germ layer above it to form the thick and flat neural plate. The neural plate folds in upon itself to form the neural tube , which will later differentiate into the spinal cord and the brain , eventually forming the central ...
In the developing chordate (including vertebrates), the neural tube is the embryonic precursor to the central nervous system, which is made up of the brain and spinal cord. The neural groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into the closed ...
The vertebrate central nervous system (CNS) is derived from the ectoderm—the outermost germ layer of the embryo. A part of the dorsal ectoderm becomes specified to neural ectoderm – neuroectoderm that forms the neural plate along the dorsal side of the embryo.
All of the organs that rise from the ectoderm such as the nervous system, teeth, hair and many exocrine glands, originate from two adjacent tissue layers: the epithelium and the mesenchyme. [8] Several signals mediate the organogenesis of the ectoderm such as: FGF , TGFβ , Wnt , and regulators from the hedgehog family .
The face and neck development of the human embryo refers to the development of the structures from the third to eighth week that give rise to the future head and neck.They consist of three layers, the ectoderm, mesoderm and endoderm, which form the mesenchyme (derived form the lateral plate mesoderm and paraxial mesoderm), neural crest and neural placodes (from the ectoderm). [1]
Vertebrates develop a neural crest that differentiates into many structures, including bones, muscles, and components of the central nervous system. Differentiation of the ectoderm into the neural crest, neural tube, and surface ectoderm is sometimes referred to as neurulation and the embryo in this phase is the neurula.
Formation of the neuroectoderm is the first step in the development of the nervous system. [1] The neuroectoderm receives bone morphogenetic protein-inhibiting signals from proteins such as noggin, which leads to the development of the nervous system from this tissue. Histologically, these cells are classified as pseudostratified columnar cells.